445476-82-4Relevant academic research and scientific papers
One-Pot Trifluoromethylative Functionalization of Amides: Synthesis of Trifluoromethylated Bis(indolyl)arylmethanes and Triarylmethanes
Pandey, Vinay Kumar,Anbarasan, Pazhamalai
, p. 12328 - 12336 (2017/12/08)
Efficient and general one-pot trifluoromethylative functionalization of amides has been accomplished for the synthesis of various trifluoromethylated bis(indolyl)arylmethane, utilizing trifluoromethyltrimethylsilane and substituted indoles as nucleophiles. The developed reaction involves the in situ generation and trapping of a trifluoromethylated iminium ion, derived from the trifluoromethylated hemiaminal of amide, with various substituted indoles. This method has been successfully extended to the synthesis of diverse trifluoromethylated triarylmethanes employing phenols as nucleophiles. Furthermore, the potential of the method was demonstrated via the two-step synthesis of a trifluoromethylated analog of a hypolipidemic and anti-obesity agent.
Concise synthesis of enantiopure α-trifluoromethyl alanines, diamines, and amino alcohols via the Strecker-type reaction
Huguenot, Florent,Brigaud, Thierry
, p. 7075 - 7078 (2007/10/03)
Diastereomerically pure α-trifluoromethyl α-amino nitriles obtained by Strecker-type reactions from chiral CF3 imines and iminium proved to be very attractive versatile intermediates for the synthesis of various α-trifluoromethyl amino compound
Some studies on nucleophilic trifluoromethylation using the shelf-stable trifluoromethylacetophenone-N,N-dimethyltrimethylsilylamine adduct
Motherwell, William B.,Storey, Lynda J.
, p. 491 - 498 (2007/10/03)
The simple thermal addition product of N,N-dimethyltrimethylsilylamine with 2,2,2-trifluoroacetophenone provides a shelf-stable reagent for nucleophilic trifluoromethylation of both the carbonyl and the imine group.
The trifluoromethylacetophenone-N,N-dimethyltrimethylsilylamine adduct - A new shelf stable reagent for nucleophilic trifluoromethylation
Motherwell, William B.,Storey, Lynda J.
, p. 646 - 648 (2007/10/03)
The simple thermal addition product of N,N-dimethyltrimethylsilylamine with trifluoromethylacetophenone provides a shelf-stable reagent for nucleophilic trifluoromethylation of the carbonyl group.
