4458-39-3

Upstream product

• 5228-61-5 5-bromo-2-nitroaniline 
• 20691-72-9 4-iodo-2-nitroaniline 

Downstream Products

• 85877-63-0 2,3,6-triphenylquinoxaline 
• 83821-08-3 Ethyl 5⁽⁶⁾-phenylbenzimidazole-2-carbamate 
• 192879-70-2 2-(3,4-dinitrophenyl)-5-phenylbenzimidazole 
• 92060-44-1 6-phenyl-quinoxaline 
• 445010-80-0 5-phenyl-1H-benzo[d]imidazol-2-amine 
• 1095200-47-7 2,3-di(furan-2-yl)-6-phenylquinoxaline 
• 1078728-22-9 C₂₆H₂₄N₂O₃ 
• 1078728-02-5 C₂₆H₂₂N₂O₂ 
• 1093377-35-5 2,2-bis(hydroxymethyl)-5-phenyl-2,3-dihydro-1H-benzo[d]imidazole 
• 1292785-83-1 2,2-bis(chloromethyl)-5-phenyl-2,3-dihydro-1H-benzo[d]imidazole 
• 445011-56-3 1-ethyl-3-(6-phenyl-1H-benzo[d]imidazol-2-yl)urea 
• 73458-38-5 6-phenylbenzo[d]thiazole-2-amine 
• 1449690-86-1 C₂₁H₂₄N₂O₂ 
• 1179813-32-1 N-hydroxy-7-(5-phenyl-1H-benzo[d]imidazol-2-yl)heptanamide 

Relevant academic research and scientific papers

Synthesis of Structurally Diverse Benzotriazoles via Rapid Diazotization and Intramolecular Cyclization of 1,2-Aryldiamines

An operationally simple method has been developed for the preparation of N-unsubstituted benzotriazoles by diazotization and intramolecular cyclization of a wide range of 1,2-aryldiamines under mild conditions, using a polymer-supported nitrite reagent and p-tosic acid. The functional group tolerance of this approach was further demonstrated with effective activation and cyclization of N-alkyl, -aryl, and -acyl ortho-aminoanilines leading to the synthesis of N1-substituted benzotriazoles. The synthetic utility of this one-pot heterocyclization process was exemplified with the preparation of a number of biologically and medicinally important benzotriazole scaffolds, including an α-amino acid analogue.

Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents

A series of benzimidazole based HDAC inhibitors have been rationally designed, synthesized and screened. The SAR of this new chemotype is described. The lead compound, 11e, showed strong activity in several cellular assays and demonstrated in vivo efficacy in mouse xenograft pancreatic cancer models.