4458-39-3

Basic information

• Product Name: biphenyl-3,4-diamine
• Synonyms: (1,1'-Biphenyl)-3,4-diamine
• CAS NO: 4458-39-3
• Molecular Formula: C₁₂H₁₂N₂
• Molecular Weight: 184.2371
• Mol File: 4458-39-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 371.4°C at 760 mmHg
• Flash Point: 212.9°C
• Density: 1.156g/cm³
• Vapor Pressure: 1.03E-05mmHg at 25°C
• Refractive Index: 1.667
• CAS DataBase Reference: biphenyl-3,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: biphenyl-3,4-diamine(4458-39-3)
• EPA Substance Registry System: biphenyl-3,4-diamine(4458-39-3)

Safety Data

• Hazardous Substances Data: 4458-39-3(Hazardous Substances Data)

Upstream product

• 20691-72-9 4-iodo-2-nitroaniline 
• 5228-61-5 5-bromo-2-nitroaniline 

Downstream Products

• 83821-08-3 Ethyl 5⁽⁶⁾-phenylbenzimidazole-2-carbamate 
• 445010-80-0 5-phenyl-1H-benzo[d]imidazol-2-amine 
• 1078728-22-9 C₂₆H₂₄N₂O₃ 
• 1078728-02-5 C₂₆H₂₂N₂O₂ 
• 1449690-86-1 C₂₁H₂₄N₂O₂ 
• 1179813-32-1 N-hydroxy-7-(5-phenyl-1H-benzo[d]imidazol-2-yl)heptanamide 

Relevant articles and documents

Synthesis of Structurally Diverse Benzotriazoles via Rapid Diazotization and Intramolecular Cyclization of 1,2-Aryldiamines

An operationally simple method has been developed for the preparation of N-unsubstituted benzotriazoles by diazotization and intramolecular cyclization of a wide range of 1,2-aryldiamines under mild conditions, using a polymer-supported nitrite reagent and p-tosic acid. The functional group tolerance of this approach was further demonstrated with effective activation and cyclization of N-alkyl, -aryl, and -acyl ortho-aminoanilines leading to the synthesis of N1-substituted benzotriazoles. The synthetic utility of this one-pot heterocyclization process was exemplified with the preparation of a number of biologically and medicinally important benzotriazole scaffolds, including an α-amino acid analogue.