863222-23-5Relevant academic research and scientific papers
Benzfluorene derivative and organic light-emitting device containing same
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Paragraph 0059; 0064, (2018/11/22)
The invention provides a benzfluorene derivative and an organic light-emitting device containing the same, and relates to the technical field of organic optoelectronic materials. According to the benzfluorene derivative and the organic light-emitting device containing the same, by connecting a substituted or unsubstituted aromatic-ring condensed imidazole derivative and aromatic-ring condensed oxazole derivative onto a benzfluorene main body, the benzfluorene derivative is obtained. The benzfluorene derivative has certain electron transportation capability, is beneficial to compounding of holes and electrons in a light-emitting layer and has good stability and high light-emitting efficiency, synthesis is simple and easy to operate, and the benzfluorene derivative can be applied to the organic light-emitting device as a light-emitting layer doped material, so that the problems can be effectively solved that in the organic light-emitting device, a blue light-emitting material is low in light-emitting efficiency and short in service life, and the organic light-emitting device containing the same has the advantages of being high in light-emitting efficiency and long in service life.
A fluorene derivative and organic light-emitting device (by machine translation)
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Paragraph 0074; 0075; 0078, (2018/11/22)
The present invention provides a fluorene derivatives and organic light-emitting device, relates to organic photoelectric material technical field. The invention through connected on the [...] substituted or unsubstituted aromatic ring fused imidazole derivatives have a fluorene derivatives, it has a certain electronic transmission capacity, is beneficial to the holes and electrons in the luminescent layer of the composite, has good stability and light-emitting efficiency, it is simple and easy to operate, and can be applied to organic light-emitting device as the dopant material in the luminescent layer, the organic light-emitting device can effectively solve the blue light-emitting material in the light emitting efficiency is low, the problem of short service life, its organic light emitting device having high luminous efficiency, long service life. (by machine translation)
Fluorene-containing compound and organic light-emitting device thereof
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Paragraph 0078; 0079; 0084, (2018/12/02)
The invention provides a fluorene-containing compound and an organic light-emitting device thereof, and relates to the technical field of organic optoelectronic materials. A fluorene body is connectedwith arylamine, substituted or non-substituted aromatic nucleus fused imidazole and oxazole derivatives to obtain the fluorene-containing compound which is a bipolar transmission material. The fluorene-containing compound is beneficial to compounding of cavities and electrons on light emitting layers, has high stability and light emission efficiency, synthesis is simple and easy to operate, and can be applied to the organic light-emitting device to serve as a light emission layer doping material, effectively solving the problems of low light emission efficiency and short service life of bluelight-emitting materials in the organic light emitting device. The organic light-emitting device of the fluorene-containing compound has the advantages of high light emission efficiency and long service life.
Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs
Nakao, Syuhei,Mabuchi, Miyuki,Shimizu, Tadashi,Itoh, Yoshihiro,Takeuchi, Yuko,Ueda, Masahiro,Mizuno, Hiroaki,Shigi, Naoko,Ohshio, Ikumi,Jinguji, Kentaro,Ueda, Yuko,Yamamoto, Masatatsu,Furukawa, Tatsuhiko,Aoki, Shunji,Tsujikawa, Kazutake,Tanaka, Akito
, p. 1071 - 1074 (2014/03/21)
A series of 1-aryl-3,4-substituted-1H-pyrazol-5-ol derivatives was synthesized and evaluated as prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors to obtain a novel anti-prostate cancer drug. After modifying 1-(1H-benzimidazol-2-yl)-3,4-dimethyl-1H-pyrazol-5-ol (1), a hit compound found during random screening using a recombinant PCA-1/ALKBH3, 1-(1H-5- methylbenzimidazol-2-yl)-4-benzyl-3-methyl-1H-pyrazol-5-ol (35, HUHS015), was obtained as a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo. The bioavailability (BA) of 35 was 7.2% in rats after oral administration. As expected, continuously administering 35 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects.
Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole derivatives
Ogino, Yoshio,Ohtake, Norikazu,Nagae, Yoshikazu,Matsuda, Kenji,Moriya, Minoru,Suga, Takuya,Ishikawa, Makoto,Kanesaka, Maki,Mitobe, Yuko,Ito, Junko,Kanno, Tetsuya,Ishihara, Akane,Iwaasa, Hisashi,Ohe, Tomoyuki,Kanatani, Akio,Fukami, Takehiro
scheme or table, p. 5010 - 5014 (2009/05/07)
Design, syntheses, and structure-activity relationships of a novel class of 2-{3-oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole NPY Y5 receptor antagonists are described. The benzimidazole structures were newly designed based on the urea linkage of our prototype Y5 receptor antagonists (2 and 3). By optimizing substituents on the benzimidazole core part of the lead compound 5a, we were able to develop a potent, orally available, and brain-penetrable Y5 selective antagonist (5k). Crown Copyright
