446-61-7

Basic information

• Product Name: 2-FLUORO-6-METHOXYANILINE
• Synonyms: 2-FLUORO-6-METHOXYANILINE;2-fluoro-6-methoxybenzenamine;2-Amino-3-fluoroanisole, 6-Fluoro-o-anisidine;2-AMino-3-fluoroanisole[2-Fluoro-6-Methoxyaniline]
• CAS NO: 446-61-7
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.14
• Mol File: 446-61-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 189.169 °C at 760 mmHg
• Flash Point: 68.208 °C
• Appearance: /
• Density: 1.177 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.15±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-6-METHOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-6-METHOXYANILINE(446-61-7)
• EPA Substance Registry System: 2-FLUORO-6-METHOXYANILINE(446-61-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 446-61-7(Hazardous Substances Data)

Upstream product

• 385-01-3 2-nitro-3-fluorophenol 
• 641-49-6 1-fluoro-3-methoxy-2-nitrobenzene 
• 4920-80-3 3-methoxy-2-nitrobenzoic acid 
• 15865-57-3 2-nitro-3-methoxybenzoyl chloride 
• 16554-47-5 3-methoxy-2-nitroaniline 

Downstream Products

• 1026693-18-4 1-(2-Fluoro-6-methoxy-phenyl)-3-pentyl-urea 
• 1073437-70-3 4-chloro-N-(2-fluoro-6-methoxyphenyl)-3-nitrobenzenesulfonamide 
• 94977-59-0 2-methyl-4-hydroxybenzothiazole 
• 5304-19-8 4-methoxy-2-methylbenzo[d]thiazole 

Relevant articles and documents

PYRIDONE-PYRIMIDINE DERIVATIVE ACTING AS KRASG12C MUTEIN INHIBITOR

Provided are a class of KRAS G12C mutein inhibitors, which relate in particular to a compound represented by formula (I), an isomer thereof, and a pharmaceutically acceptable salt thereof.

Dibenzothiophene Sulfoximine as an NH3 Surrogate in the Synthesis of Primary Amines by Copper-Catalyzed C?X and C?H Bond Amination

Readily accessible dibenzothiophene sulfoximine is an NH3 surrogate allowing the preparation of free anilines by copper-catalyzed cross-coupling reactions with aryl iodides or amides followed by radical S?N bond cleavage. The one-pot/two-step r