446-59-3

Usage

Uses

Used in Organic Synthesis:
2-Bromo-3-fluoroanisole is used as an intermediate in the production of more complex organic compounds. Its unique combination of bromine and fluorine atoms, along with the methoxy group, makes it a valuable building block for creating a variety of molecules with potential applications in different industries.
Used in Pharmaceutical Industry:
2-Bromo-3-fluoroanisole is used as a key intermediate in the synthesis of pharmaceutical compounds. Its reactivity and structural features allow for the development of new drugs with improved properties, such as increased potency, selectivity, or reduced side effects.
Used in Agrochemical Industry:
2-Bromo-3-fluoroanisole is used as a starting material for the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties enable the creation of effective and environmentally friendly products for agricultural use.
Used in Material Science:
2-Bromo-3-fluoroanisole is used as a component in the development of new materials with specific properties, such as improved thermal stability, chemical resistance, or electrical conductivity. Its versatility in organic synthesis allows for the creation of materials with tailored characteristics for various applications.

InChI:InChI=1/C7H8FNO/c1-10-6-4-2-3-5(8)7(6)9/h2-4H,9H2,1H3

Upstream product

• 446-61-7 2-fluoro-6-methoxyphenylamine 
• 456-49-5 1-fluoro-3-methoxybenzene 
• 443-81-2 2-bromo-3-fluorophenol 
• 74-88-4 methyl iodide 
• 641-49-6 1-fluoro-3-methoxy-2-nitrobenzene 

Downstream Products

• 146746-55-6 9-(2-fluoro-6-methoxyphenyl)phenanthrene 
• 146746-64-7 1-(2-fluoro-6-methoxyphenyl)phenanthrene 
• 75626-21-0 C₉H₁₂BFO₃ 
• 53308-23-9 5-methoxy-1,4-dihydro-1,4-methanonaphthalene 
• 1155877-70-5 3-bromo-2-fluoro-4-methoxybenzaldehyde 
• 286836-05-3 7-bromo-6-fluorobenzofuran 
• 286836-03-1 7-bromo-6-methoxybenzofuran 
• 113028-78-7 1-(2-fluoro-6-methoxyphenyl)piperazine 

Relevant academic research and scientific papers

Phenyl acetate derivatives, fluorine-substituted on the phenyl group, as rapid recovery hypnotic agents with reflex depression

We report the synthesis of novel, potentially hypnotic fluorine-substituted phenyl acetate derivatives. We describe the structure-activity relationship that led us to the promising derivative: ethyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-5-ethoxy-2-fluorophenyl) acetate (55). The unique pharmacological features of compound 55 are its relatively high affinity for the GABAA receptor, together with a unique affinity for the NMDA receptor, different to propanidid and AZD3043. In animal models, compound 55 showed stronger hypnotic potency and longer duration of LORR than propanidid and AZD3043, but also maintained a rapid recovery time to walking and behavioral recovery. In particular, compound 55 displayed reflex depression during infusion.

Ring-Substituted y1,2-Bis(4-hydroxyphenyl)ethylenediamine>dichloroplatinum(II) Complexes: Compounds with a Selective Effect on the Hormone-Dependent Mammary Carcinoma

dichloroplatinum(II) complexes with one substituent in the 2-position (CH3, CF3, F, Br, I: meso- and dl-1-PtCl2, meso-(3-5)-PtCl2, meso-(7 and 8)-PtCl2) or two substituents in the 2,6-position (CH3, Cl: meso-2-PtCl2, meso- and dl-6-PtCl2) in both benzene rings were synthesized and tested for estrogenic and toxic activities.Two complexes (meso-6-PtCl2 and meso-7-PtCl2) possess both effects.In comparative tests on estrogen receptor positive and negative mammary tumors in cell culture (MCF 7, ER+ and MDA-MB 231, ER-) and in animals (MXT, ER+ and MXT, ER-, mouse), meso-6-PtCl2 shows a selective effect on the estrogen receptor positive mammary carcinoma.A further increase of efficacy was achieved with the water-soluble (sulfato)platinum(II) derivative (meso-6-PtSO4).On the DMBA-induced hormone dependent mammary carcinoma of the SD rat, meso-6-PtSO4 is significantly more active than its ligand (meso-6) and cisplatin.

107. Substitution electrophile aromatique dans l'anhydride sulfureux liquide. Etude cinetique de la reaction de bromination d'anisoles monosubstitues. Transmission des effets electroniques et caracteristiques de l'etat de transition

Reactivity-structure correlations for anisole and eleven of its substituted derivatives established from bromination rate constants in liquid SO2, unlike observations in water, show the reaction to be highly sensitive to substituent effects, (ρ+H2O = -7.1; ρ+SO2 = -10.51).This result is ascribed to the solvation of the methoxy group which decreases the conjugation of para-substituted (ρ+O = -9.70) compared to that of ortho-substituted derivatives (ρ+p = -8.86).The highly solvated transition state lies far from reactants on the reaction coordinate and the positive charge developed in this state is nearly unity.