446064-66-0

Basic information

• Product Name: (E)-(S)-4-((2R,3S)-2-Amino-3-methyl-pentanoylamino)-5-(4-triisopropylsilanyloxy-phenyl)-pent-2-enoic acid allyl ester
• Synonyms: (E)-(S)-4-((2R,3S)-2-Amino-3-methyl-pentanoylamino)-5-(4-triisopropylsilanyloxy-phenyl)-pent-2-enoic acid allyl ester
• CAS NO: 446064-66-0
• Molecular Weight: 516.797
• Mol File: 446064-66-0.mol

Chemical Properties

• CAS DataBase Reference: (E)-(S)-4-((2R,3S)-2-Amino-3-methyl-pentanoylamino)-5-(4-triisopropylsilanyloxy-phenyl)-pent-2-enoic acid allyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(S)-4-((2R,3S)-2-Amino-3-methyl-pentanoylamino)-5-(4-triisopropylsilanyloxy-phenyl)-pent-2-enoic acid allyl ester(446064-66-0)
• EPA Substance Registry System: (E)-(S)-4-((2R,3S)-2-Amino-3-methyl-pentanoylamino)-5-(4-triisopropylsilanyloxy-phenyl)-pent-2-enoic acid allyl ester(446064-66-0)

Safety Data

• Hazardous Substances Data: 446064-66-0(Hazardous Substances Data)

Upstream product

• 446064-64-8 (E)-(S)-4-tert-Butoxycarbonylamino-5-(4-triisopropylsilanyloxy-phenyl)-pent-2-enoic acid allyl ester 
• 735327-63-6 (S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(triisopropylsilyloxy)phenyl)propanoate 
• 151133-13-0 [(S)-1-Formyl-2-(4-triisopropylsilanyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 104127-76-6 allyl (triphenylphosphoranylidene)acetate 
• 446064-65-9 (E)-(S)-4-((2R,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-5-(4-triisopropylsilanyloxy-phenyl)-pent-2-enoic acid allyl ester 

Downstream Products

• 446064-67-1 C₆₈H₉₄Cl₃N₉O₁₆Si 
• 446064-72-8 C₆₅H₉₀Cl₃N₉O₁₆Si 
• 475503-59-4 C₇₁H₁₀₅N₉O₁₆Si₂ 

Relevant articles and documents

Total synthesis of cyclotheonamides E2 and E3: Application of cyano ylide methodology

A total synthesis of cyclotheonamides E2 and E3 is reported. A key step in the synthesis involves the formation of the α-keto amide linkage by application of the cyano ylide activation of a carboxyl group as developed in our earlier syntheses of cyclic peptides in the family of protease inhibitors.

Application of cyano ylide methodology to the synthesis of cyclotheonamides E2 and E3

A total synthesis of cyclotheonamides E2 and E3 is reported. A key step in the synthesis involves the formation of the α-keto amide linkage by application of the cyano ylide activation of a carboxyl group as developed in our earlier syntheses of cyclic peptide protease inhibitors.