446064-67-1Relevant articles and documents
Total synthesis of cyclotheonamides E2 and E3: Application of cyano ylide methodology
Wasserman, Harry H.,Zhang, Rui
, p. 3743 - 3746 (2007/10/03)
A total synthesis of cyclotheonamides E2 and E3 is reported. A key step in the synthesis involves the formation of the α-keto amide linkage by application of the cyano ylide activation of a carboxyl group as developed in our earlier syntheses of cyclic peptides in the family of protease inhibitors.