446069-99-4Relevant academic research and scientific papers
CHK-, PDK- AND AKT-INHIBITORY PYRIMIDINES, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS
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Page 83, (2008/06/13)
This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases.
Identification of potent and novel α4β1 antagonists using in silico screening
Singh, Juswinder,Abraham, William M.,Adams, Steven P.,Van Vlijmen, Herman,Liao, Yusheng,Lee, Wen-Cherng,Cornebise, Mark,Harris, Mary,Shu, I-Hsiang,Gill, Alan,Cuervo, Julio H.
, p. 2988 - 2993 (2007/10/03)
The antigen α4β1 (very late antigen-4, VLA-4) plays an important role in the migration of white blood cells to sites of inflammation. It has been implicated in the pathology of a variety of diseases including asthma, multiple sclerosis, and rheumatoid art
