4461-11-4Relevant academic research and scientific papers
Carbonic anhydrase inhibitors. Part 61. Quantum chemical QSAR of a group of benzenedisulfonamides
Clare, Brian W.,Supuran, Claudiu T.
, p. 463 - 474 (2007/10/03)
The synthesis of a large group of benzenesulfonamides containing both a primary and secondary sulfonamide moiety is described. These compounds are powerful inhibitors of several isozymes of the enzyme carbonic anhydrase. Separate QSAR's are given for inhi
Syntheses of N4-(Alkyl or arylsulfonyl)sulfanilyl Derivatives
Cremlyn, R. J.,Swinbourne, F. J.,Devlukia, P.,Shode, O.
, p. 249 - 253 (2007/10/02)
2,4-Dichloro, 2,5-dichloro and 3,4-dichloro-benzene-sulfanilides react with chlorosulfonic acid at low temperature to give good yields of the corresponding dichlorobenzenesulfonyl sulfanilyl chlorides.A number of chlorides have been converted into derivatives by reaction with nucleophiles, such as dimethylamine, hydrazine and sodium azide.N4-Acetamidobenzenesulfonylsulfanilyl derivatives have been prepared by the condensation of N4-acetylsulfanilyl chloride with the appropriate sulfanilyl derivative.Methylsulfonanilide reacts with chlorosulfonic acid to give N4-(methylsulfonyl)sulfanilyl chloride.The compounds have been tested for their antibacterial and antifungal activity.
