446235-25-2

Upstream product

• 57260-73-8 N-BOC-1,2-diaminoethane 
• 103-46-8 S-benzylmercaptoacetic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1026454-82-9 (benzyloxycarbonyl-{[2-(2-benzylsulfanyl-acetylamino)-ethylcarbamoyl]-methyl}-amino)-acetic acid 
• 446235-27-4 {[2-(2-benzylsulfanyl-acetylamino)-ethylcarbamoyl]-methyl}-carbamic acid benzyl ester 
• 446235-29-6 N-{[2-(2-benzylsulfanyl-acetylamino)-ethylcarbamoyl]-methyl}-oxalamic acid ethyl ester 
• 1026298-62-3 {[2-(2-benzylsulfanyl-acetylamino)-ethylaminooxalyl]-amino}-acetic acid ethyl ester 
• 1026246-33-2 N-[2-(2-benzylsulfanyl-acetylamino)-ethyl]-oxalamic acid 

Relevant academic research and scientific papers

Synthesis and biological characteristics of the technetium-99m triamide derivatives of mercaptoacetyltriglycine (MAG3)

A number of MAG3-derivatives, containing the three-amide functions modified by inverting the sequence -CO-NH- to -NH-CO- in the first-and/or second-amide functions, have been labelled with 99mTc in order to study the renal characteristics of the resulting MAG3-derivatives versus the reference 99mTc-MAG3. The 99mTc-MAG3-derivatives displayed HPLC-profiles similar to that of 99mTc-MAG3. Furthermore, in mice they exhibited biological behaviour comparable or even superior to 99mTc-MAG3, which indicates that the sequence of the first- and/or second-amide bond in 99mTc-MAG3 affects the biological behaviour only to a limited degree. However, in baboon the plasma clearance of the 99mTc-MAG3-derivatives was relatively slower than 99mTc-MAG3, which underlines the inter-species variability. Copyright

Synthesis, labelling and biological characteristics of derivatives of mercaptoacetyltriglycine with two amide functions

Eight novel derivatives of MAG3, containing in their structure two instead of three amide functions, have been synthesized and evaluated. The synthesized ligands were labelled with 99mTc by exchange labelling at 100°C and/or by a dir

Synthesis, radiolabelling and biological evaluation of terminal oxamide derivatives of mercaptoacetyltriglycine

99mTc-MAG3 is widely used in clinical nuclear medicine as a potential replacement of 131I-OIH for renal function studies. The terminal carbonylglycine in the MAG3 backbone is assumed to be essential for maintain