446271-40-5Relevant academic research and scientific papers
Toward synthesis of alpha-alkyl amino glycines (A3G), new amino acid surrogates.
Yaouancq, Loic,Rene, Loic,Tran Huu Dau, Marie-Elise,Badet, Bernard
, p. 5408 - 5411 (2007/10/03)
A general method giving access to protected alpha-alkyl amino glycines (A3G) 4 from the previously described precursor alpha-isopropylthioglycine 1 is described. In the presence of N-bromosuccinimide, displacement of the thiol by a large variety of amines afforded the corresponding racemic amino acid mimics. The efficiency of the reaction was strongly dependent on the protective groups of the nucleophile used in the condensation.
