446277-25-4

Upstream product

• 100-39-0 benzyl bromide 
• 172077-88-2 octyl 3,4-O-isopropylidene-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside 
• 111-87-5 octanol 
• 74513-17-0 n-octyl β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside 
• 4753-07-5 2,3,6,2',3',4',6'-hepta-O-acetyl-lactosyl bromide 
• 172077-87-1 octyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1->4)-2,3,6-tri-O-acetyl-β-D-glucopyranoside 

Downstream Products

• 446277-26-5 octyl 2,6-di-O-benzyl-β-D-galactopyranosyl-(1->4)-2,3,6-tri-O-benzyl-β-D-glucopyranoside 

Relevant academic research and scientific papers

Observations on chemical and enzymatic approaches to α-2,3-sialylated octyl β-lactoside

A comparison of chemical and chemo-enzymatic syntheses of α-2,3-sialylated octyl lactoside is reported. The chemical approach, starting from lactose and sialic acid, required 14 steps and proceeded in 5% overall yield; poor α-selectivity in the sialylation step necessitated a difficult and low yielding separation of anomers. A chemoenzymatic approach, employing recombinant Trypanosoma cruzi trans-sialidase to effect the key sialylation reaction, required 10 steps and gave a similar overall yield. Whereas the chemo-enzymatic synthesis required only three chromatographic purification steps overall, the chemical synthesis required at least nine.