446285-73-0

Usage

Uses

Used in Pharmaceutical Industry:
N-Methyl-4-(tributylstannyl)imidazole is used as a reagent for the synthesis of methylthiopyrazole epothilone B, a highly potent anticancer drug. Its role in the synthesis process is crucial, as it contributes to the formation of the drug's molecular structure, which is responsible for its potent anticancer activity.
In the synthesis of methylthiopyrazole epothilone B, N-Methyl-4-(tributylstannyl)imidazole serves as a key intermediate, facilitating the formation of the desired product with high efficiency and selectivity. This application highlights the importance of N-Methyl-4-(tributylstannyl)imidazole in the development of novel and effective cancer treatments, potentially improving the lives of patients suffering from various types of cancer.

Upstream product

• 1461-22-9 tributyltin chloride 
• 71759-87-0 4-iodo-1-methyl-1H-imidazole 

Downstream Products

• 761446-27-9 4-[1-Phenyl-1-(1-methylimidazol-4-yl)methylene]piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF

An N-(azaaryl)cyclolactam-1-carboxamide derivative having a structure of formula (I), a preparation method therefor, and a use thereof are disclosed in the application. Each substituent are defined in the specification and claims. The series of compounds of the application can be widely applied in the preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease or metastatic disease, particularly for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, primary tumor site metastasis or osseous metastasis cancer, and are expected to be developed into a new generation of CSF-1R inhibitor drugs.

MYST FAMILY HISTONE ACETYLTRANSFERASE INHIBITORS

The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

CHEMICAL SYNTHESIS OF A HIGHLY POTENT EPOTHILONE

A highly active synthetic epothilone compound whose activity exceeds that of either epothilone EpoA or EpoB when assayed as a cytotoxic agent against a cancer cell line is disclosed as is a pharmaceutical composition containing the synthetic epothilone.

Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: wherein: Z is Q is selected from the group consisting of: —W— is