71759-87-0Relevant articles and documents
Expedient total syntheses of preclathridine A and clathridine A
Koswatta, Panduka B.,Lovely, Carl J.
, p. 4998 - 5000 (2009)
A short and operationally simple total synthesis of two Leucetta-derived marine alkaloids has been developed, which rely on position specific halogen-metal exchange to introduce the benzyl-substituted side chain. Introduction of the C2 amine group by lith
MYST FAMILY HISTONE ACETYLTRANSFERASE INHIBITORS
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Paragraph 0293-0295; 0292, (2019/06/19)
The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
Total synthesis and cytotoxicity of Leucetta alkaloids
Koswatta, Panduka B.,Kasiri, Sabha,Das, Jayanta K.,Bhan, Arunoday,Lima, Heather M.,Garcia-Barboza, Beatriz,Khatibi, Nicole N.,Yousufuddin, Muhammed,Mandal, Subhrangsu S.,Lovely, Carl J.
, p. 1608 - 1621 (2017/02/26)
The total synthesis of a number of representative natural products isolated from Leucetta and Clathrina sponges containing a polysubstituted 2-aminoimidazole are described. These syntheses take advantage of the site specific metallation reactions of 4,5-diiodoimidazoles resulting in the syntheses of three different classes of Leucetta derived natural products. The cytotoxicities of these natural products, along with several precursors in MCF7 cells were determined through an MTT growth assay. For comparative purposes a series of naphthimidazole-containing family members are included.
