446286-61-9

Basic information

• Product Name: 5-BROMO-2-(PYRROLIDIN-1-YL)PYRIMIDINE
• Synonyms: 5-BROMO-2-(PYRROLIDIN-1-YL)PYRIMIDINE;5-Bromo-2-pyrrolidinopyrimidine;1-(5-Bromopyrimidin-2-yl)pyrrolidine, 5-Bromo-2-(pyrrolidin-1-yl)-1,3-diazine;5-bromo-2-1-pyrrolidinylpyrimidine;ChemDiv3_009394;IDI1_027304
• CAS NO: 446286-61-9
• Molecular Formula: C₈H₁₀BrN₃
• Molecular Weight: 228.09
• EINECS: 200-528-9
• Product Categories: Organohalides;Pyrimidine
• Mol File: 446286-61-9.mol

Chemical Properties

• Boiling Point: 345.0±34.0 °C(Predicted)
• Appearance: /
• Density: 1.555±0.06 g/cm3(Predicted)
• PKA: 2.44±0.42(Predicted)
• CAS DataBase Reference: 5-BROMO-2-(PYRROLIDIN-1-YL)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-(PYRROLIDIN-1-YL)PYRIMIDINE(446286-61-9)
• EPA Substance Registry System: 5-BROMO-2-(PYRROLIDIN-1-YL)PYRIMIDINE(446286-61-9)

Safety Data

• Hazard Codes: Xi,Xn
• Hazardous Substances Data: 446286-61-9(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
5-Bromo-2-(pyrrolidin-1-yl)pyrimidine is used as a building block for the synthesis of various biologically active compounds. Its unique structure and properties make it a promising candidate for the development of new drugs with potential therapeutic applications.
Used in Drug Discovery:
In the field of drug discovery, 5-Bromo-2-(pyrrolidin-1-yl)pyrimidine serves as a valuable chemical entity for the identification and optimization of novel drug candidates. Its versatile utility allows researchers to explore its potential in treating various diseases and conditions.
Used in Scientific Research:
5-Bromo-2-(pyrrolidin-1-yl)pyrimidine is used as a research tool in the study of pyrimidine-based molecules and their interaction with biological targets. Its structure and properties provide insights into the design and development of new pyrimidine-based compounds with improved pharmacological properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Bromo-2-(pyrrolidin-1-yl)pyrimidine is utilized for the synthesis of biologically active compounds with potential therapeutic applications. Its unique structure and properties contribute to the discovery of new drugs and the advancement of medicinal chemistry.
Overall, 5-Bromo-2-(pyrrolidin-1-yl)pyrimidine is a versatile chemical compound with significant potential in various applications across the fields of medicinal chemistry, drug discovery, and scientific research. Its unique structure and properties make it a valuable asset in the development of novel therapeutic agents and the study of pyrimidine-based molecules.

Upstream product

• 123-75-1 pyrrolidine 
• 32779-36-5 5-Bromo-2-chloropyrimidine 

Downstream Products

• 1620067-30-2 C₂₈H₂₇N₅O₂ 

Relevant articles and documents

The Cyclopropane Ring as a Reporter of Radical Leaving-Group Reactivity for Ni-Catalyzed C(sp3)-O Arylation

The ability to understand and predict reactivity is essential for the development of new reactions. In the context of Ni-catalyzed C(sp3)-O functionalization, we have developed a unique strategy employing activated cyclopropanols to aid the design and optimization of a redox-active leaving group for C(sp3)-O arylation. In this chemistry, the cyclopropane ring acts as a reporter of leaving-group reactivity, since the ring-opened product is obtained under polar (2e) conditions, and the ring-closed product is obtained under radical (1e) conditions. Mechanistic studies demonstrate that the optimal leaving group is redox-active and are consistent with a Ni(I)/Ni(III) catalytic cycle. The optimized reaction conditions are also used to synthesize a number of arylcyclopropanes, which are valuable pharmaceutical motifs.