446286-61-9 Usage
General Description
5-Bromo-2-(pyrrolidin-1-yl)pyrimidine is a chemical compound that belongs to the class of pyrimidine derivatives. It is characterized by the presence of a bromine atom at the 5th position and a pyrrolidin-1-yl group at the 2nd position of the pyrimidine ring. 5-BROMO-2-(PYRROLIDIN-1-YL)PYRIMIDINE has potential applications in medicinal chemistry and drug discovery, as it can serve as a building block for the synthesis of various biologically active compounds. Additionally, its structure and properties make it suitable for use as a research tool in the study of pyrimidine-based molecules and their interaction with biological targets. Overall, 5-Bromo-2-(pyrrolidin-1-yl)pyrimidine is a valuable chemical entity with versatile utility in pharmaceutical and scientific research.
Check Digit Verification of cas no
The CAS Registry Mumber 446286-61-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,6,2,8 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 446286-61:
(8*4)+(7*4)+(6*6)+(5*2)+(4*8)+(3*6)+(2*6)+(1*1)=169
169 % 10 = 9
So 446286-61-9 is a valid CAS Registry Number.
446286-61-9Relevant articles and documents
The Cyclopropane Ring as a Reporter of Radical Leaving-Group Reactivity for Ni-Catalyzed C(sp3)-O Arylation
Mills, L. Reginald,Monteith, John J.,Dos Passos Gomes, Gabriel,Aspuru-Guzik, Alán,Rousseaux, Sophie A. L.
supporting information, p. 13246 - 13254 (2020/09/01)
The ability to understand and predict reactivity is essential for the development of new reactions. In the context of Ni-catalyzed C(sp3)-O functionalization, we have developed a unique strategy employing activated cyclopropanols to aid the design and optimization of a redox-active leaving group for C(sp3)-O arylation. In this chemistry, the cyclopropane ring acts as a reporter of leaving-group reactivity, since the ring-opened product is obtained under polar (2e) conditions, and the ring-closed product is obtained under radical (1e) conditions. Mechanistic studies demonstrate that the optimal leaving group is redox-active and are consistent with a Ni(I)/Ni(III) catalytic cycle. The optimized reaction conditions are also used to synthesize a number of arylcyclopropanes, which are valuable pharmaceutical motifs.
