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446299-81-6

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  • High Quality 99% 446299-81-6 (S) - 6-chloro-3,4-dihydro-2h-thieno [3,2-e] - 1,2-thiazine-4-alcohol 1,1-dioxide Manufacturer

    Cas No: 446299-81-6

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446299-81-6 Usage

Uses

[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Under a nitrogen atmosphere, N-(5-bromo-3-methyl-2-pyridinyl)-N-methylbenzamide 30.0 g was dissolved in 150 mL of tetrahydrofuran, triisopropyl borate 22.0 g was added. The reaction mixture was colled to-60 .DEGREE CELSIUS., n-butyl lithium (1.56 mol/L n-hexane solution) 69 mL was added dropwise required to between 20 minutes, and the mixture was stirred for 15 minutes at the same temperature.After raising the temperature of the reaction mixture at-20 .DEGREE CELSIUS., 390 mL of water was added dropwise, it was stirred for 30 min at room temperature,the aqueous layer was separated. The aqueous layer was fractionated and HCl 1 mol/L was added to adjust the pH at 4.5,the precipitate was collected by filtration, 6-[benzoyl(methyl)amino]-5-methyl-3-pyridinylboric acid 18.5 g was obtained as colorless solid.

Check Digit Verification of cas no

The CAS Registry Mumber 446299-81-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,6,2,9 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 446299-81:
(8*4)+(7*4)+(6*6)+(5*2)+(4*9)+(3*9)+(2*8)+(1*1)=186
186 % 10 = 6
So 446299-81-6 is a valid CAS Registry Number.

446299-81-6Downstream Products

446299-81-6Relevant articles and documents

CRYSTALLINE FORM OF OZENOXACIN AND PROCESSES FOR PREPARATION THEREOF

-

, (2020/05/12)

The present invention relates to a crystalline form of 1-cyclopropyl-8-methyl-7- (5-methyl-6-(methylamino)pyridin-3-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid the compound of formula-1, which is represented by the following structural formula-1. The

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