446308-66-3Relevant academic research and scientific papers
Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase
Sinha, Shweta,Doble, Mukesh,Manju
, p. 34 - 50 (2018/09/13)
Human 5-Lipoxygenase (5-LOX) is a key enzyme targeted for asthma and inflammation. Zileuton, the only drug against 5-LOX, was withdrawn from the market due to several problems. In the present study, the performance of rationally designed conjugates of thi
Crystal structures and antifungal activities of fluorine-containing thioureido complexes with nickel(II)
Li, Chun,Yang, Wen,Liu, Huanhuan,Li, Mengying,Zhou, Weiqun,Xie, Juan
, p. 15737 - 15749 (2014/01/17)
Ni(II) complexes with N-2-fluorobenzoylpiperidine-1-carbothioimidate (L2-), N-4-fluorobenzoylpiperidine-1-carbothioimidate (L3-), N-2- fluorobenzoylmorpholine- 1-carbothioimidate (L5-) and N-4- fluorobenzoylmorpholine-1-carbothioimidate (L6-) have been synthesized and characterized by elemental analysis, FTIR and 1H-NMR. The crystal structures of three ligands (HL2, HL3 and HL6) and the corresponding Ni(II) complexes ([Ni(L2)2], [Ni(L3)2] and [Ni(L6)2]) have been determined by X-ray diffraction. The antifungal activities of the Ni(II) complexes together and the corresponding ligands against the fungi Botrytis cinerea, Trichoderma spp., Myrothecium and Verticillium spp. have been investigated. The experimental results showed that the ligands and their complexes have antifungal abilities. When the fluorine was substituted on the para-benzoyl moiety, the antifungal activity of the ligands was obviously increased. Moreover, the ligands were stronger than their complexes in inhibiting fungal activities. The antifungal ability of HL6 is especially strong, and similar to that of the commercial fungicide fluconazole.
Crystal structures and antimicrobial activities of copper(II) complexes of fluorine-containing thioureido ligands
Liu, Huanhuan,Yang, Wen,Zhou, Weiqun,Xu, Yunlong,Xie, Juan,Li, Mengying
, p. 387 - 394 (2013/10/22)
Cu(II) complexes with N-4-fluorobenzoylpiperidine-1-carbothioimidate (L1), N-2-fluorobenzoylpiperi-dine-1-carbothioimidate (L2) and 2-fluorobenzoate (L3) have been synthesized and characterized by elemental analysis, Fourier Transform infrared (FT-IR), Ul
