446311-34-8

Basic information

• Product Name: 2-[4-(4-Methoxyphenyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• Synonyms: 2-[4-(4-Methoxyphenyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-(4'-Methoxy-4-biphenylyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS NO: 446311-34-8
• Molecular Formula: C19H23BO3
• Molecular Weight: 310.19512
• Mol File: 446311-34-8.mol
• Article Data: 15

Chemical Properties

• Melting Point: 130-134 °C
• Boiling Point: 428.3±38.0 °C(Predicted)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-[4-(4-Methoxyphenyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(4-Methoxyphenyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(446311-34-8)
• EPA Substance Registry System: 2-[4-(4-Methoxyphenyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(446311-34-8)

Safety Data

• Hazardous Substances Data: 446311-34-8(Hazardous Substances Data)

Usage

Uses

2-(4''-Methoxy-4-biphenylyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Upstream product

• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 58743-83-2 4-bromo-4'-methoxylbiphenyl 
• 18158-44-6 4-dimethylamino-4'-methoxybiphenyl 
• 73183-34-3 bis(pinacol)diborane 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 5467-74-3 4-Bromophenylboronic acid 
• 696-62-8 para-iodoanisole 
• 104-94-9 4-methoxy-aniline 
• 624-38-4 para-diiodobenzene 
• 16881-71-3 4'-methoxy-1,1'-biphenyl-4-ol 
• 950511-16-7 1-(2,3-dihydro-1H-naphtho[1,8-de]-1,3,2-diazaborinyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 73852-88-7 2-(4-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 1447973-44-5 C₁₉H₂₃BO₄ 
• 1447973-73-0 C₁₉H₂₃BO₄ 

Relevant articles and documents

Photoinduced Deaminative Borylation of Unreactive Aromatic Amines Enhanced by CO2

Herein, direct unreactive C-N borylation of aromatic amines by a photocatalyst was achieved. The C-N borylation of aromatic amines with bis(pinacolato)diboron (B2pin2) proceeded using a pyrene catalyst under light irradiation to afford desired borylated products and aminoborane as a byproduct. The yield of the borylated product improved under a CO2 atmosphere which probably reduced the inhibitory effect of aminoborane. Mechanistic studies suggested that the C-N bond cleavage and C-B bond formation proceeded via a concerted pathway.

COMPOUNDS FOR THE MODULATION OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9)

The present disclosure relates to novel compounds capable of binding to PCSK9, thereby modulating PCSK9 biological activity. Also provided are compositions comprising these compounds, methods of preparing the compounds, and methods for use of the compounds in the treatment of PCSK9-related conditions and diseases.

Development and Mechanistic Studies of Iron-Catalyzed Construction of Csp2-B Bonds via C-O Bond Activation

Herein we describe an iron-catalyzed borylation of alkenyl and aryl carbamates through the activation of a C-O bond. This protocol exhibits high efficiency, a broad substrate scope, and the late-stage borylation of biorelevant compounds, thus providing potential applications in medicinal chemistry. Moreover, this method enables orthogonal transformations of phenol derivatives and also offers good opportunities for the synthesis of multisubstituted arenes. Preliminary mechanistic studies suggest that a FeII/FeIII catalytic cycle via a radical pathway might be involved in the reaction.