446839-81-2Relevant academic research and scientific papers
6-Guanidinopurine nucleosides and their analogues
Cěsnek, Michal,Holy, Antonín,Masojídková, Milena
, p. 2985 - 2996 (2002)
A general synthetic approach to 6-guanidinopurines, their ribonucleosides, 2-deoxyribonucleosides, acyclic nucleoside analogues and acyclic nucleoside phosphonates was developed. The approach consists in the reaction of the 6-chloropurine derivatives with guanidine solution in DMF under DABCO catalysis. This method was used to synthesize 6-guanidinopurine and 2-amino-6-guanidinopurine derivatives. Acyclic nucleosides and acyclic nucleoside phosphonates were also obtained by alkylation of the 6-guanidinopurine bases.
