446866-83-7

Basic information

• Product Name: 3-(MORPHOLINOMETHYL)BENZALDEHYDE
• Synonyms: 4-(3-CARBOXALDEHYDEBENZYL)MORPHOLINE;3-MORPHOLIN-4-YLMETHYL-BENZALDEHYDE;3-(MORPHOLINOMETHYL)BENZALDEHYDE;3-(Morpholin-4-ylmethyl)benzaldehyde 95+%;3-(morpholin-4-ylmethyl)benzaldehyde(SALTDATA: FREE);4-(3-Formylbenzyl)morpholine
• CAS NO: 446866-83-7
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.25
• Mol File: 446866-83-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 63 °C
• Boiling Point: 321.9 °C at 760 mmHg
• Flash Point: 148.5 °C
• Appearance: /
• Density: 1.149 g/cm³
• Vapor Pressure: 0.000289mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: 3-(MORPHOLINOMETHYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(MORPHOLINOMETHYL)BENZALDEHYDE(446866-83-7)
• EPA Substance Registry System: 3-(MORPHOLINOMETHYL)BENZALDEHYDE(446866-83-7)

Safety Data

• Hazard Codes: C
• HazardClass: IRRITANT
• Hazardous Substances Data: 446866-83-7(Hazardous Substances Data)

Usage

General Description

3-(MORPHOLINOMETHYL)BENZALDEHYDE, also known as 3-benzaldehydemorpholine, is a chemical compound with the molecular formula C10H11NO2. It is a white to light yellow solid that is used in the production of pharmaceuticals, agrochemicals, and dyes. 3-(MORPHOLINOMETHYL)BENZALDEHYDE is widely used as a building block in the synthesis of various heterocyclic compounds and has been studied for its potential biological and pharmacological properties. Additionally, 3-(MORPHOLINOMETHYL)BENZALDEHYDE has been found to exhibit antimicrobial and antifungal properties, making it a valuable ingredient in the formulation of antimicrobial agents and preservatives. Overall, this chemical compound has a wide range of potential applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C12H15NO2/c14-10-12-3-1-2-11(8-12)9-13-4-6-15-7-5-13/h1-3,8,10H,4-7,9H2

Upstream product

• 823-78-9 meta-bromobenzyl bromide 
• 68-12-2 N,N-dimethyl-formamide 
• 364793-82-8 4-(3-bromobenzyl)morpholine 
• 857283-91-1 C₁₂H₁₄N₂O 
• 28188-41-2 m-(bromomethyl)benzonitrile 

Downstream Products

• 942949-16-8 6-Bromo-2-(3-morpholin-4-ylmethyl-phenyl)-7-(4-pyridin-3-ylmethyl-piperazin-1-yl)-3H-imidazo[4,5-b]pyridine 
• 1029800-54-1 (R)-2-(3-morpholin-4-ylmethyl-phenyl)-thiazolidine-4-carboxylic acid 
• 1402709-73-2 4-(3-(6-chloro-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)morpholine 
• 1095381-30-8 4-(3-(6-bromo-7-(4-(4-chlorobenzyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)morpholine 

Relevant articles and documents

Design and synthesis of benzopyran-based inhibitors of the hypoxia-inducible factor-1 pathway with improved water solubility

While progress has been made in treating cancer, cytotoxic chemotherapeutic agents are still the most widely used drugs and are associated with severe side-effects. Drugs that target unique molecular signalling pathways are needed for treating cancer with low or no intrinsic toxicity to normal cells. Our goal is to target hypoxic tumours and specifically the hypoxia inducible factor (HIF) pathway for the development of new cancer therapies. To this end, we have previously developed benzopyran-based HIF-1 inhibitors such as arylsulfonamide KCN1. However, KCN1 and its earlier analogs have poor water solubility, which hamper their applications. Herein, we describe a series of KCN1 analogs that incorporate a morpholine moiety at various positions. We found that replacing the benzopyran group of KCN1 with a phenyl group with a morpholinomethyl moiety at the para positions had minimal effect on potency and improved the water solubility of two new compounds by more than 10-fold compared to KCN1, the lead compound.

AMINO-FUNCTIONAL CHALCONES

The invention provides novel amino-functionalised chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also discl