446873-84-3

Basic information

• Product Name: 8-Azabicyclo[3.2.1]oct-6-ene-8-carboxylic acid, 3-oxo-, phenylmethyl ester
• CAS NO: 446873-84-3
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.289
• Mol File: 446873-84-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 8-Azabicyclo[3.2.1]oct-6-ene-8-carboxylic acid, 3-oxo-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Azabicyclo[3.2.1]oct-6-ene-8-carboxylic acid, 3-oxo-, phenylmethyl ester(446873-84-3)
• EPA Substance Registry System: 8-Azabicyclo[3.2.1]oct-6-ene-8-carboxylic acid, 3-oxo-, phenylmethyl ester(446873-84-3)

Safety Data

• Hazardous Substances Data: 446873-84-3(Hazardous Substances Data)

Upstream product

• 1542468-56-3 C₁₅H₁₃Br₂NO₃ 
• 56857-08-0 benzyl 1H-pyrrole-1-carboxylate 
• 22612-89-1 1,1,3,3-tetrabromoacetone 

Downstream Products

• 1187618-07-0 benzyl 7-oxo-3-oxa-9-azatricyclo[3.3.1.0(2,4)]nonane-9-carboxylate 
• 647027-72-3 (1S,3R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-8-aza-bicyclo[3.2.1]oct-6-ene-8-carboxylic acid benzyl ester 
• 646036-44-4 (1S,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-8-aza-bicyclo[3.2.1]oct-6-ene-8-carboxylic acid benzyl ester 
• 646036-41-1 N-benzyloxycarbonyl-spiro{8-azabicyclo[3.2.1]oct-6-ene-3,2'-[1,3]dioxolane} 

Relevant articles and documents

Synthesis and biological evaluation of both enantiomers of [ 18F]flubatine, promising radiotracers with fast kinetics for the imaging of α4β2-nicotinic acetylcholine receptors

Both enantiomers of the epibatidine analogue flubatine display high affinity towards the α4β2 nicotinic acetylcholine receptor (nAChR) in vitro, accompanied by negligible interactions with diverse off-target proteins. Extended single dose toxicity studies in rodent indicated a NOEL (No Observed Effect Level) of 6.2 μg/kg for (-)-flubatine and 1.55 μg/kg for (+)-flubatine. We developed syntheses for both flubatine enantiomers and their corresponding precursors for radiolabeling. The newly synthesized trimethylammonium precursors allowed for highly efficient 18F- radiolabelling in radiochemical yields >60% and specific activities >750 GBq/μmol, thus making the radioligands practical for clinical investigation.