447-03-0

Basic information

• Product Name: 2-(4-fluorophenyl)-3-oxobutyronitrile
• Synonyms: 2-(4-fluorophenyl)-3-oxobutyronitrile;α-Acetyl-4-fluorobenzeneacetonitrile;1-Cyano-1-(4-fluorophenyl)propan-2-one;2-(4-fluorophenyl)-3-oxobutanenitrile ;a-Acetyl-4-fluoro-benzeneacetonitrile
• CAS NO: 447-03-0
• Molecular Formula: C₁₀H₈FNO
• Molecular Weight: 177.1750232
• EINECS: 207-178-0
• Mol File: 447-03-0.mol

Chemical Properties

• Melting Point: 90 °C
• Boiling Point: 237.7°Cat760mmHg
• Flash Point: 97.5°C
• Appearance: /
• Density: 1.175
• Vapor Pressure: 0.0442mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-fluorophenyl)-3-oxobutyronitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-3-oxobutyronitrile(447-03-0)
• EPA Substance Registry System: 2-(4-fluorophenyl)-3-oxobutyronitrile(447-03-0)

Safety Data

• Hazardous Substances Data: 447-03-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-(4-fluorophenyl)-3-oxobutyronitrile is used as a building block in organic synthesis for the creation of complex organic molecules. Its unique structure and reactivity facilitate the synthesis of a wide range of compounds, making it a valuable component in the development of new chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(4-fluorophenyl)-3-oxobutyronitrile is utilized as a precursor in the development of potential drug candidates. Its characteristic fluorophenyl group and nitrile functionality contribute to the design of novel therapeutic agents with specific biological activities.
Used in Chemical Industry:
2-(4-fluorophenyl)-3-oxobutyronitrile is employed as a versatile precursor for the preparation of various compounds with diverse applications across the chemical industry. Its nitrile functional group allows for the synthesis of a broad spectrum of products, enhancing its utility in multiple chemical processes and applications.

InChI:InChI=1/C10H8FNO/c1-7(13)10(6-12)8-2-4-9(11)5-3-8/h2-5,10H,1H3

Upstream product

• 459-22-3 4-fluorophenylacetonitrile 
• 141-78-6 ethyl acetate 

Downstream Products

• 702709-77-1 4-(4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine 
• 863400-29-7 2-(4-fluorophenyl)-3-methoxybut-2-ene nitrile 
• 1160169-14-1 (E)-3-amino-2-(4-fluorophenyl)but-2-enenitrile 
• 1404447-03-5 3-(4-fluorophenyl)-2-methyl-5-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 62538-16-3 4-(4-fluorophenyl)-3-methyl-1H-pyrazol-5-amine 
• 1404447-07-9 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1404449-60-0 3-(4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione 
• 1404449-61-1 5,7-dichloro-3-(4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidine 
• 1404449-62-2 5-chloro-3-(4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1404447-09-1 3-(4-fluorophenyl)-2-methyl-5-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 

Relevant articles and documents

NEW ANTI-MALARIAL AGENTS

The present invention is related to a use of pyrazole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrazole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders

The invention relates to methods of using the compounds of the invention, including pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof, as well as pharmaceutical compositions comprising the same, in the treatment of Eph receptor-related (e.g., neurological) injuries and disorders. The invention also relates to modulating the activity of an Eph receptor in a cell, stimulating neural regeneration, and reversing neuronal degeneration, by administering a compound of the invention to a cell or subject in an effective amount.

FUNGICIDAL HETEROCYCLIC COMPOUNDS

A compound which can specifically or selectively expresses an antifungal activity with a broad spectrum, based on the functional mechanism of 1,6-β-glucan synthesis inhibition, is provided, and an antifungal agent which comprises such a compound, a salt thereof or a solvate thereof is provided. A compound represented by the following formula (I), a salt thereof or a solvate thereof.

Synthesis of N-substituted indole derivatives via PIFA-mediated intramolecular cyclization

(Chemical Equation Presented) A variety of N-arylated and N-alkylated indole derivatives were synthesized by way of a phenyliodine bis(trifluoroacetate) (PIFA)-mediated intramolecular cyclization. This novel method allows for the construction of an indole skeleton by joining the N-atom on the side chain to the benzene ring at the last synthetic step. Other novel pyrrole-fused aromatic compounds can also be achieved by this method.

Organic compounds

The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.

PYRAZOLO[1,5-A]PYRIMIDIN-7-YL-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES

The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.