447-05-2

Basic information

• Product Name: 5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate
• Synonyms: 5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate;[5-hydroxy-4-(hydroxymethyl)-6-methyl-pyridin-3-yl]methoxyphosphonic acid;Pyridoxine 5'-phosphate;5-Hydroxy-6-methyl-3,4-pyridinedimethanol 3-phosphoric acid;5-Hydroxy-6-methylpyridine-3,4-dimethanol 3-phosphoric acid;Phosphoric acid 4-(hydroxymethyl)-5-hydroxy-6-methyl-3-pyridylmethyl ester;Pyridoxine 5'-phosphoric acid;(5-hydroxy-6-methyl-4-methylol-3-pyridyl)methyl dihydrogen phosphate
• CAS NO: 447-05-2
• Molecular Formula: C₈H₁₂NO₆P
• Molecular Weight: 249.157741
• EINECS: 207-179-6
• Mol File: 447-05-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 638.5°Cat760mmHg
• Flash Point: 340°C
• Appearance: /
• Density: 1.628g/cm³
• Vapor Pressure: 3.54E-17mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: 5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate(447-05-2)
• EPA Substance Registry System: 5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate(447-05-2)

Safety Data

• Hazardous Substances Data: 447-05-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 447-05-2 differently. You can refer to the following data:
1. Pyridoxol 5'-phosphate is a vitamer of Vitamin B6 complex (P991715), an enzyme cofactor in many reactions of amino acid metabolism.
2. Pyridoxol 5''-phosphate is a vitamer of Vitamin B6 complex (P991715), an enzyme cofactor in many reactions of amino acid metabolism.

InChI:InChI=1/C8H12NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2,10-11H,3-4H2,1H3,(H2,12,13,14)

Upstream product

• 54-47-7 pyridoxal 5'-phosphate 
• 56-23-5 tetrachloromethane 
• 7732-18-5 water 
• 190079-18-6 Phosphoric acid mono-((2R,3S)-2,3-dihydroxy-4-oxo-pentyl) ester 
• 58-56-0 pyridoxal hydrochloride 

Downstream Products

• 54-47-7 pyridoxal 5'-phosphate 

Relevant articles and documents

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Biosynthesis of vitamin B6: Enzymatic conversion of 1-deoxy-D-xylulose- 5-phosphate to pyridoxol phosphate [14]

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Interconversions of different forms of vitamin B6 in tobacco plants

There are six different vitamin B6 (VB6) forms, pyridoxal (PL), pyridoxamine (PM), pyridoxine (PN), pyridoxal 5′-phosphate (PLP), pyridoxamine 5′-phosphate (PMP), and pyridoxine 5′-phosphate (PNP), of which PLP is the active form. Although plants are a major source of VB6 in the human diet, and VB6 plays an important role in plants, the mechanisms underlying the interconversions of different VB 6 forms are not well understood. In this study, in vitro tobacco plants were grown on Murashige and Skoog (MS) basal media supplemented with 100 mg/L of PM, PL or PN and the abundance of the different B6 vitamers in leaf tissue was quantified by high performance liquid chromatography (HPLC). The total amount of VB6 was about 3.9 μg/g fresh weight of which PL, PM, PN, PLP and PMP accounted for 23%, 14%, 37%, 20% and 6%, respectively. Tobacco plants contained a trace amount of PNP. Supplementation of the culture medium with any of the non-phosphorylated vitamers resulted in an increase in total VB6 by about 10-fold, but had very little impact on the concentrations of the endogenous phosphorylated vitamers. Administration of either PM or PN increased their endogenous levels more than the levels of any other endogenous B6 vitamers. PL supplementation increased the levels of plant PN and PM significantly, but not that of PL, suggesting that efficient conversion pathways from PL to PN and PM are present in tobacco. Additionally, maintenance of a stable level of PLP in the plant is not well-correlated to changes in levels of non-phosphorylated forms.