447-47-2Relevant academic research and scientific papers
1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists
Travins, Jeremy M.,Bernotas, Ronald C.,Kaufman, David H.,Quinet, Elaine,Nambi, Ponnal,Feingold, Irene,Huselton, Christine,Wilhelmsson, Anna,Goos-Nilsson, Annika,Wrobel, Jay
scheme or table, p. 526 - 530 (2010/05/19)
A series of 1-(3-aryloxyaryl)benzimidazoles incorporating a sulfone substituent (6) was prepared. High affinity LXR ligands were identified (LXRβ binding IC50 values 10 nM), some with excellent agonist potency and efficacy in a functional assay of LXR activity measuring ABCA1 mRNA increases in human macrophage THP1 cells. The compounds were typically stable in liver microsome preparations and had good oral exposure in mice.
