384-32-7Relevant articles and documents
Selective C-H trifluoromethylation of benzimidazoles through photoredox catalysis
Gao, Guo-Lin,Yang, Chao,Xia, Wujiong
supporting information, p. 1041 - 1044 (2017/02/05)
The protocol presented here is a new strategy for visible light induced C-H trifluoromethylation at C4 of benzimidazoles using Togni's reagent in the presence of fac-Ir(ppy)3. Its advantages are its operational simplicity, mild reaction conditions, low catalyst loading and wide substrate scope in which electron-withdrawing, electron-donating groups and different protecting groups are tolerated.
1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists
Travins, Jeremy M.,Bernotas, Ronald C.,Kaufman, David H.,Quinet, Elaine,Nambi, Ponnal,Feingold, Irene,Huselton, Christine,Wilhelmsson, Anna,Goos-Nilsson, Annika,Wrobel, Jay
scheme or table, p. 526 - 530 (2010/05/19)
A series of 1-(3-aryloxyaryl)benzimidazoles incorporating a sulfone substituent (6) was prepared. High affinity LXR ligands were identified (LXRβ binding IC50 values 10 nM), some with excellent agonist potency and efficacy in a functional assay of LXR activity measuring ABCA1 mRNA increases in human macrophage THP1 cells. The compounds were typically stable in liver microsome preparations and had good oral exposure in mice.