4474-99-1Relevant academic research and scientific papers
Catalytic Transfer Hydrogenation in Synthesis of Substance P
Sivanandaiah, K. M.,Rangaraju, N. S.
, p. 787 - 792 (2007/10/02)
The utility of catalytic transfer hydrogenation (CTH) in the synthesis of longer peptides has been demonstrated by the stepwise synthesis of Substance P in the solution phase.The technique of CTH using formic acid as a hydrogen donor provides a facile method for the removal of protecting groups such as benzyloxycarbonyl and nitro in the synthesis of medium-sized peptides also.Except in the case of glutaminyl peptides where the purity and yield are affected to some extent by cyclization, the products are generally pure requiring minimum purification and the yields are good.
