447401-91-4

Basic information

• Product Name: Ethyl 1-Ethylpyrazole-4-carboxylate
• Synonyms: Ethyl 1-Ethylpyrazole-4-carboxylate;ethyl 1-ethyl-1H-pyrazole-4-carboxylate
• CAS NO: 447401-91-4
• Molecular Formula: C8H12N2O2
• Molecular Weight: 168.19308
• Mol File: 447401-91-4.mol

Chemical Properties

• Boiling Point: 253.9±13.0 °C(Predicted)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• PKA: 0.13±0.10(Predicted)
• CAS DataBase Reference: Ethyl 1-Ethylpyrazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 1-Ethylpyrazole-4-carboxylate(447401-91-4)
• EPA Substance Registry System: Ethyl 1-Ethylpyrazole-4-carboxylate(447401-91-4)

Safety Data

• Hazardous Substances Data: 447401-91-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 1-Ethylpyrazole-4-carboxylate is used as a reactant for the preparation of N-heteroaryl benzenesulfonamides, which are known as CCR9 inhibitors. These inhibitors play a crucial role in the treatment of various diseases, particularly those related to the immune system and inflammation. By targeting the CCR9 receptor, these compounds can modulate the immune response and potentially offer therapeutic benefits in the management of autoimmune disorders and other conditions.

Upstream product

• 37622-90-5 4-ethoxycarbonylpyrazole 
• 75-03-6 ethyl iodide 

Downstream Products

• 1359029-13-2 ethyl 1-ethyl-5-{2-[4-(trifluoromethyl)phenyl]ethenyl}-1H-pyrazole-4-carboxylate 
• 1359029-12-1 ethyl 1-ethyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole-4-carboxylate 
• 400858-54-0 1-ethyl-1H-pyrazole-4-carboxylic acid 
• 905307-04-2 (1-ethyl-1H-pyrazole-4-yl)methanol 

Relevant articles and documents

BENZODIAZEPINE DERIVATIVES FOR TREATING A RESPIRATORY SYNCYTIAL VIRUS (RSV) INFECTION

Benzodiazepine derivatives of formula (I): wherein: each of R1 and R2 is independently H or halo; R3 is H, C1-C6 alkyl, -NHR8 or -OR'; either (i) a, c, and e are all bonds, with b, d and f absent; or b, d and f are all bonds, with a, c and e absent; R4 is H or a group selected from C1-C6 alkyl, C3-C6 cycloalkyl and 4- to 10-membered heterocyclyl, the group being unsubstituted or substituted; R5 is H or halo; R6 is -OR8, -NR8R9 or -R8; R7 is H or halo; each of R8 and R9 is independently H or a group selected from C1-C6 alkyl, C3-C6 cycloalkyl and 4- to 10-membered heterocyclyl, the group being unsubstituted or substituted; R' is H or C1-C6 alkyl; and one of V and W is CH and the other is N or CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

1-((1H-PYRAZOL-4-YL)METHYL)-3-(PHENYL)-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS GPR139 ANTAGONISTS FOR THE TREATMENT OF E.G. DEPRESSION

The present invention refers to compounds of formula (I). The present invention also relates to compounds of formula (I) for use as G Protein coupled Receptor 139 (GPR139) antagonists in methods of medical treatment of e.g. depression, Alzheimer's disease

3-((1H-PYRAZOL-4-YL)METHYL)-6'-(PHENYL)-2H-(1,2'-BIPYRIDIN)-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS GPR139 ANTAGONISTS FOR USE IN A METHOD OF TREATMENT OF E.G. DEPRESSION

The present invention refers to compounds of formula (I). The present invention also relates to compounds of formula (I) for use as G Protein coupled Receptor 139 (GPR139) antagonists in methods of medical treatment of e.g. depression, Alzheimer's disease

COMPOUNDS USEFUL AS MODULATORS OF TRPM8

The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

SUBSTITUTED PYRAZOLOQUINAZOLINONES AND PYRROLOQUINAZOLINONES AS ALLOSTERIC MODULATORS OF GROUP II METABOTROPIC GLUTAMATE RECEPTORS

The present invention relates to the pyrazoloquinazolinone and pyrroloquinazolinone derivatives of the general formula (I), as well as pharmaceutical compositions containing them, and their use in the treatment and/or prophylaxis of conditions associated with altered glutamatergic signalling and/or functions, and/or conditions which can be affected by alteration of glutamate level or signalling in mammals, in particular their use in the treatment and/or prophylaxis of acute and chronic neurological and/or psychiatric disorders.

Herbicide compositions

A herbicidal composition which comprises i) an isoxazoline derivative represented by the following general formula (I) or its salt and ii) at least one compound selected from the Group A: Formula (I) wherein R1, R2, R3, R4, R5 and R6 are defined in the specification.

ISOXAZOLINE DERIVATIVE AND HERBICIDE COMPRISING THE SAME AS ACTIVE INGREDIENT

An isoxazoline derivative represented by the following general formula [I]: wherein R1 and R2 may be the same or different and are each an alkyl group; ???R3, R4, R5 and R6 are each a hydrogen atom; ???Y is an optionally substituted 5- to 6-membered aromatic heterocyclic group or fused aromatic heterocyclic group having a hetero atom selected from a nitrogen atom, a oxygen atom and a sulfur atom; and ???n is an integer of 0 to 2. The isoxazoline derivative has an excellent herbicidal effect and an excellent selectivity between crop and weed.