447402-87-1Relevant articles and documents
Synthesis and antiviral activity of new anti-HIV amprenavir bioisosteres
Rocheblave, Luc,Bihel, Frédéric,De Michelis, Céline,Priem, Ghislaine,Courcambeek, Jér?me,Bonnet, Brice,Chermann, Jean-Claude,Kraus, Jean-Louis
, p. 3321 - 3324 (2002)
Starting from the chemical structure of the recent FDA-approved anti-HIV drug Amprenavir (Agenerase), a potent HIV-protease inhibitor, we have designed new series of Amprenavir bioisoteres in which the methylene group of the benzyl group was replaced by a