447408-29-9

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 447408-26-6 3-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrole-2,5-dione 
• 447408-25-5 3-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-bromo-1-methylpyrrole-2,5-dione 
• 447408-23-3 3-bromo-1-methyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrrole-2,5-dione 
• 98-09-9 benzenesulfonyl chloride 
• 3005-27-4 3,4-dibromo-1-methyl-2,5-dihydropyrrole-2,5-dione 
• 271-63-6 7-Azaindole 

Relevant academic research and scientific papers

First synthesis of symmetrical and non-symmetrical aza indolocarbazoles derivatives

A new family of aza-indolocarbazoles 2-3 was built from protected 3-(3-indolyl)-4-bromo-N-methylmaleimide in a few efficient steps. Symmetrical and non-symmetrical products were obtained. Regioselectivity of anionic condensation was controlled. A possible selective deprotection between an N-Boc and N-benzenesulphonyl group using mild basic conditions was confirmed.

Synthesis and biological evaluation of 7-azaindolocarbazoles

In the course of a program aimed at designing antitumor agents containing an indolocarbazole framework, an efficient synthetic scheme based on the use of 3,4-dibromo-N-methylmaleimide and 7-azaindole has been developed to elaborate a series of mono- and di-aza derivatives of arcyriaflavin. The procedure was further exploited to introduce a hydroxyl group at different positions on the indole moiety of the non-symmetrical compounds. The DNA binding capacity and cytotoxic potential of these 7-azaindolocarbazole derivatives was evaluated.