447415-25-0

Upstream product

• 71-43-2 benzene 
• 412299-83-3 4-bromo-2-(phenylcarbonyl)benzoic acid 
• 86-90-8 4-bromophthalic anhydride 
• 1332697-10-5 6-bromo-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid 
• 447423-14-5 6-bromo-3-(hydroxymethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one 
• 583837-70-1 6-bromo-1-oxo-4-phenyl-1H-isochromene-3-carboxylic acid 
• 447417-81-4 6-bromo-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile 
• 447423-15-6 6-bromo-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one 

Downstream Products

• 447417-18-7 2-{[3-(Aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl]sulfanyl}acetamide 
• 447418-45-3 3-[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl]propanamide hydrochloride 
• 447416-90-2 (2E)-3-[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl]prop-2-enamide hydrochloride 
• 447425-78-7 tert-butyl {[6-(3-amino-3-oxopropyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate 
• 447424-09-1 tert-butyl ({6-[(1E)-3-amino-3-oxoprop-1-en-1-yl]-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl}methyl)carbamate 
• 447425-77-6 3-[3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl]propanoic acid 
• 447424-08-0 (2E)-3-[3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl]prop-2-enoic acid 
• 447425-76-5 ethyl 3-[3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl]propanoate 
• 447424-07-9 ethyl (2E)-3-[3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl]prop-2-enoate 
• 447416-14-0 3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carbonitrile hydrochloride 
• 1332697-01-4 3-(aminomethyl)-N,N-dimethyl-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide hydrochloride 
• 1332697-00-3 3-(aminomethyl)-N-methyl-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide hydrochloride 
• 447415-37-4 3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide hydrochloride 
• 447415-33-0 3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxylic acid hydrochloride 

Relevant academic research and scientific papers

Design of potent dipeptidyl peptidase IV (DPP-4) inhibitors by employing a strategy to form a salt bridge with Lys554

We report a design strategy to obtain potent DPP-4 inhibitors by incorporating salt bridge formation with Lys554 in the S1′ pocket. By applying the strategy to the previously identified templates, quinoline 4 and pyridines 16a, 16b, and 17 have been identified as subnanomolar or nanomolar inhibitors of human DPP-4. Docking studies suggested that a hydrophobic interaction with Tyr547 as well as the salt bridge interaction is important for the extremely high potency. The design strategy would be useful to explore a novel design for DPP-4 inhibitors having a distinct structure with a unique binding mode.

Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: A new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554

The design, synthesis, and structure-activity relationships of a new class of potent and orally active non-peptide dipeptidyl peptidase IV (DPP-4) inhibitors, 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones, are described. We hypothesized that the 4-ph

Fused heterocyclic compounds

The present invention provides a compound of the formula: wherein ring A is an optionally substituted 5 to 10-membered aromatic ring; R1 and R2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond and the like; and L is a divalent hydrocarbon group, and a salt thereof, except 3-(aminomethyl)-2,6,7-trimethyl-4-phenyl-1(2H)-isoquinolinone, 3-(aminomethyl)-2-methyl-4-phenyl-1(2H)-isoquinolinone, 3-(aminomethyl)-6-chloro-2-methyl-4-phenyl-1(2H)-isoquinolinone and 3-(aminomethyl)-2-isopropyl-4-phenyl-1(2H)-isoquinolinone. The compound shows a superior peptidase-inhibitory activity and is useful as an agent for the prophylaxis or treatment of diabetes and the like.