447417-81-4

Basic information

• Product Name: 3-Isoquinolinecarbonitrile, 6-bromo-1,2-dihydro-2-(2-methylpropyl)-1-oxo-4-phenyl-
• CAS NO: 447417-81-4
• Molecular Formula: C20H17BrN2O
• Molecular Weight: 381.272
• Mol File: 447417-81-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Isoquinolinecarbonitrile, 6-bromo-1,2-dihydro-2-(2-methylpropyl)-1-oxo-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Isoquinolinecarbonitrile, 6-bromo-1,2-dihydro-2-(2-methylpropyl)-1-oxo-4-phenyl-(447417-81-4)
• EPA Substance Registry System: 3-Isoquinolinecarbonitrile, 6-bromo-1,2-dihydro-2-(2-methylpropyl)-1-oxo-4-phenyl-(447417-81-4)

Safety Data

• Hazardous Substances Data: 447417-81-4(Hazardous Substances Data)

Upstream product

• 412299-83-3 4-bromo-2-(phenylcarbonyl)benzoic acid 
• 447425-19-6 C₂₀H₁₉BrN₂O₂ 
• 100-58-3 phenylmagnesium bromide 
• 71-43-2 benzene 
• 86-90-8 4-bromophthalic anhydride 

Downstream Products

• 838840-98-5 6-tert-butoxy-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinecarbonitrile 
• 1557155-02-8 2-[(3-cyano-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl)oxy]acetamide 
• 447416-95-7 2-{[3-(aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl]oxy}acetamide 
• 1557155-00-6 6-hydroxy-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinecarbonitrile 
• 447415-25-0 3-(aminomethyl)-6-bromo-2-(2-methyl)propyl-4-phenylisoquinolin-1(2H)-one 

Relevant articles and documents

Development of Large-Scale Synthesis using a Palladium-Catalyzed Cross-Coupling Reaction for an Isoquinolone Derivative as a Potent DPP-4 Inhibitor

An efficient large-scale synthesis of a novel DPP-4 inhibitor 1, an isoquinolone derivative bearing an aminomethyl group at the 3-position and carbamoylmethoxy group at the 6-position, is described. We have developed an effective and convenient synthetic