447417-81-4

Upstream product

• 86-90-8 4-bromophthalic anhydride 
• 71-43-2 benzene 
• 100-58-3 phenylmagnesium bromide 
• 447425-19-6 C₂₀H₁₉BrN₂O₂ 
• 412299-83-3 4-bromo-2-(phenylcarbonyl)benzoic acid 

Downstream Products

• 838840-98-5 6-tert-butoxy-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinecarbonitrile 
• 1557155-02-8 2-[(3-cyano-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl)oxy]acetamide 
• 447416-95-7 2-{[3-(aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl]oxy}acetamide 
• 1557155-00-6 6-hydroxy-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinecarbonitrile 
• 447415-25-0 3-(aminomethyl)-6-bromo-2-(2-methyl)propyl-4-phenylisoquinolin-1(2H)-one 

Relevant academic research and scientific papers

Development of Large-Scale Synthesis using a Palladium-Catalyzed Cross-Coupling Reaction for an Isoquinolone Derivative as a Potent DPP-4 Inhibitor

An efficient large-scale synthesis of a novel DPP-4 inhibitor 1, an isoquinolone derivative bearing an aminomethyl group at the 3-position and carbamoylmethoxy group at the 6-position, is described. We have developed an effective and convenient synthetic

Fused heterocyclic compounds

The present invention provides a compound of the formula: wherein ring A is an optionally substituted 5 to 10-membered aromatic ring; R1 and R2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond and the like; and L is a divalent hydrocarbon group, and a salt thereof, except 3-(aminomethyl)-2,6,7-trimethyl-4-phenyl-1(2H)-isoquinolinone, 3-(aminomethyl)-2-methyl-4-phenyl-1(2H)-isoquinolinone, 3-(aminomethyl)-6-chloro-2-methyl-4-phenyl-1(2H)-isoquinolinone and 3-(aminomethyl)-2-isopropyl-4-phenyl-1(2H)-isoquinolinone. The compound shows a superior peptidase-inhibitory activity and is useful as an agent for the prophylaxis or treatment of diabetes and the like.