447425-19-6

Basic information

• Product Name: C₂₀H₁₉BrN₂O₂
• CAS NO: 447425-19-6
• Molecular Weight: 399.287
• Mol File: 447425-19-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₉BrN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₉BrN₂O₂(447425-19-6)
• EPA Substance Registry System: C₂₀H₁₉BrN₂O₂(447425-19-6)

Safety Data

• Hazardous Substances Data: 447425-19-6(Hazardous Substances Data)

Upstream product

• 412299-83-3 4-bromo-2-(phenylcarbonyl)benzoic acid 
• 63315-37-7 2-(N-(2-methylpropyl)amino)acetonitrile 
• 100-58-3 phenylmagnesium bromide 
• 71-43-2 benzene 
• 86-90-8 4-bromophthalic anhydride 

Downstream Products

• 1557155-02-8 2-[(3-cyano-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl)oxy]acetamide 
• 447416-95-7 2-{[3-(aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl]oxy}acetamide 
• 447417-81-4 6-bromo-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile 
• 838840-98-5 6-tert-butoxy-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinecarbonitrile 
• 1557155-00-6 6-hydroxy-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinecarbonitrile 

Relevant articles and documents

Development of Large-Scale Synthesis using a Palladium-Catalyzed Cross-Coupling Reaction for an Isoquinolone Derivative as a Potent DPP-4 Inhibitor

An efficient large-scale synthesis of a novel DPP-4 inhibitor 1, an isoquinolone derivative bearing an aminomethyl group at the 3-position and carbamoylmethoxy group at the 6-position, is described. We have developed an effective and convenient synthetic