447459-98-5

Upstream product

• 368-91-2 4-methoxybenzene-1-sulfonyl fluoride 
• 182141-70-4 N-[(1S)-1-(4-bromophenyl)ethyl]-2,2,2-trifluoroacetamide 
• 5335-87-5 4,4'-dimethoxyphenyl disulfide 
• 447460-42-6 2,2,2-trifluoro-N-(1-{4-[4-methoxy-2-(4-methoxy-phenylsulfanyl)-benzenesulfonyl]-phenyl}-ethyl)-acetamide 

Downstream Products

• 447459-99-6 (S)-1-{4-[4-Methoxy-2-(4-methoxy-benzenesulfonyl)-benzenesulfonyl]-phenyl}-ethylamine 

Relevant academic research and scientific papers

Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: Identification of a lead and initial SAR studies

A novel class of cannabinoid CB2 receptor ligands is described. These triaryl bis-sulfones are nanomolar inhibitors of the CB2 receptor and show high selectivity over the cannabinoid CB1 receptor. One example of this new class decreases ligand-induced GTPγS binding to recombinant CB2 cell membranes, identifying the compound as a CB2-selective inverse agonist.

Cannabinoid receptor ligands

The invention relates to compounds of the formula a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit anti-inflammatory and immunodulatory activity. Also disclosed are pharmac