447461-86-1

Upstream product

• 447461-94-1 (R)-4-tert-butyldimethylsilyloxy-2-(4-dimethylamino-2-methoxy-phenyl)-butanol 
• 637762-21-1 (R)-3-(4-Dimethylamino-2-methoxy-phenyl)-butan-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 447461-92-9 (R)-4-benzoyloxy-3-(4-dimethylamino-2-methoxy-phenyl)-butyraldehyde 
• 637762-29-9 Benzoic acid (R)-2-(4-dimethylamino-2-methoxy-phenyl)-4-hydroxy-butyl ester 
• 447462-12-6 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-dimethylamino-2-methoxy-phenyl)-butyric acid methyl ester 
• 447461-93-0 benzoic acid 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-dimethylamino-2-methoxy-phenyl)-butyl ester 
• 15799-79-8 3-methoxy-N,N-dimethylaniline 
• 447462-08-0 (R)-4-oxo-2-(4-dimethylamino-2-methoxyphenyl)-butyric acid methyl ester 
• 447461-85-0 (R)-3-(4-dimethylamino-2-methoxy-phenyl)butyraldehyde 

Relevant academic research and scientific papers

The enantioselective organocatalytic 1,4-addition of electron-rich benzenes to α,β-unsaturated aldehydes

The first enantioselective organocatalytic alkylation of electron-rich benzene rings with α,β-unsaturated aldehydes has been accomplished. The use of iminium catalysis has provided a new strategy for the enantioselective construction of benzylic stereogenicity, an important chiral synthon for natural product and medicinal agent synthesis. The (2S,5S)-5-benzyl-2-tert-butylimidazolidinone amine catalyst has been found to mediate the conjugate addition of a wide variety of substituted and unsubstituted anilines to unsaturated aldehydes. A diverse spectrum of aldehyde substrates can also be accommodated in this new organocatalytic transformation. While catalyst quantities of 10 mol % were generally employed in this study, successful alkylations conducted with catalyst loadings as low as 1 mol % are described. Copyright