Technology Process of (R)-3-(4-dimethylamino-2-methoxyphenyl)-butanol tert-butyldimethylsilyl ether
There total 11 articles about (R)-3-(4-dimethylamino-2-methoxyphenyl)-butanol tert-butyldimethylsilyl ether which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: (2S,5S)-5-benzyl-2-tert-butyl-3-methyl-imidazolidinone; HCl / CHCl3; dioxane / 24 h / -20 °C
2.1: 303 mg / NaBH4 / CH2Cl2; ethanol / 0.08 h
3.1: 400 mg / triethylamine; DMAP / CH2Cl2 / 1 h
4.1: 25.4 mg / MeLi / diethyl ether; hexane / 0.08 h / 0 °C
5.1: MsCl; DMAP; Et3N / tetrahydrofuran / 2 h
5.2: 99.9 mg / LiAlH4 / tetrahydrofuran / 6 h
With
hydrogenchloride; dmap; sodium tetrahydroborate; (2S,5S)-5-benzyl-2-tert-butyl-3-methyl-imidazolidinone; methyllithium; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; dichloromethane; chloroform;
DOI:10.1021/ja025981p
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 453 mg / triethylamine; DMAP / CH2Cl2 / 1 h
2.1: 201 mg / LiAlH4 / diethyl ether / 0.08 h / 0 °C
3.1: MsCl; DMAP; Et3N / tetrahydrofuran / 2 h
3.2: 99.9 mg / LiAlH4 / tetrahydrofuran / 6 h
With
dmap; lithium aluminium tetrahydride; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja025981p
- Guidance literature:
-
(R)-4-tert-butyldimethylsilyloxy-2-(4-dimethylamino-2-methoxy-phenyl)-butanol;
With
dmap; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran;
for 2h;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 6h;
Further stages.;
DOI:10.1021/ja025981p
