447463-95-8

Upstream product

• 63762-78-7 1-fluoro-2-methoxy-4-methylbenzene 
• 124-38-9 carbon dioxide 
• 63762-79-8 2-fluoro-5-methylphenol 

Downstream Products

• 447463-21-0 (3-{4-[1-(2-fluoro-3-methoxy-5-methyl-benzyloxy)-ethyl]-2-methoxy-5-nitro-phenoxy}-propyl)-carbamic acid tert-butyl ester 
• 447463-68-5 1-bromomethyl-2-fluoro-3-methoxy-5-methylbenzene 
• 307975-07-1 (2-fluoro-3-methoxy-5-methyl-phenyl)-methanol 

Relevant academic research and scientific papers

COMPOUNDS FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS

Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries

A method for encoding solid-phase split/mix combinatorial libraries using the chemical shift of synthetic fluoroarenes ('F-codes') has been developed. They have wide chemical shift dispersion and are detectable at the sub-μmol level. 19F NMR is