44812-81-9

Usage

Uses

Used in Pharmaceutical Industry:
L-Alanine, 2-propenyl ester (9CI) is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and enhance the properties of existing ones.
Used in Food Industry:
L-Alanine, 2-propenyl ester (9CI) is used as a flavoring agent and food additive, leveraging its capacity to impart or enhance specific tastes and aromas in food products.
Used in Chemical Industry:
L-Alanine, 2-propenyl ester (9CI) is utilized in the production of various chemical products, taking advantage of its stable and low reactive nature to ensure consistent and reliable outcomes in chemical processes.

Upstream product

• 113707-00-9 N-Boc-alanine allyl ester 
• 56-41-7 L-alanin 
• 107-18-6 allyl alcohol 

Downstream Products

• 116912-14-2 PhAc-Ile-Ala-OAll 
• 182690-16-0 (S)-2-{(S)-2-[((S)-2-{(S)-3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-phenyl-propionyloxy]-3-phenyl-propionyloxy}-3-methyl-butyryl)-methyl-amino]-propionylamino}-propionic acid allyl ester 
• 753487-73-9 C₆₅H₈₃N₅O₁₀Si 
• 753487-79-5 benzoic acid 4-(1-allyloxycarbonyl-ethylcarbamoyl)-4-{[3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-methyl-amino}-2-methyl-butyl ester 
• 855315-83-2 Benzoic acid (2R,4S)-4-((S)-1-allyloxycarbonyl-ethylcarbamoyl)-4-({(2S,3R)-2-amino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionyl}-methyl-amino)-2-methyl-butyl ester 
• 855315-80-9 Benzoic acid (2R,4S)-4-((S)-1-allyloxycarbonyl-ethylcarbamoyl)-2-methyl-4-methylamino-butyl ester 
• 753487-77-3 Benzoic acid (2R,4S)-4-((S)-1-allyloxycarbonyl-ethylcarbamoyl)-4-(tert-butoxycarbonyl-methyl-amino)-2-methyl-butyl ester 
• 303766-95-2 (3R,5S)-4-acetyl-3-[(1-adamantyl)methyl]-1-(2-chlorobenzyl)-5-[(1S)-allyloxycarbonylethyl]aminocarbonyl-2,7-dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1,4]diazonine 
• 116864-74-5 Noc-Phe-Ala-OAllyl 
• 120902-58-1 (S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-propionic acid allyl ester 

Relevant academic research and scientific papers

Solid-phase synthesis of peptide selenoesters: Via a side-chain anchoring strategy

Peptide selenoesters have recently emerged as key building blocks for the ligation-based assembly of large polypeptides and proteins. Herein, we report an efficient solid-phase method for the high yielding and epimerisation-free synthesis of peptide selenoesters using a side-chain immobilisation strategy.

Solid-phase synthesis of piperazinones via disrupted ugi condensation

The first application of aziridine aldehyde dimers in solid-phase synthesis is reported. The solid-supported disrupted Ugi condensation between an aziridine aldehyde dimer, isonitrile, and backbone-anchored amino acids delivered N-acyl aziridine intermediates, which were reacted with nucleophiles to yield the corresponding piperazinones. Subsequent cleavage from the resin provided a diverse set of 2,3,6-trisubstituted piperazinones starting from various amino acids, aziridine aldehydes, and nucleophiles.

The palladium-catalyzed asymmetric α-allylations of carbonyl compounds with chiral allyl esters via enamines and imines

A novel and excellent method for asymmetric α-allylation of carbonyl compounds via their chiral enamines or imines bearing allyl esters has been developed. Readily available chiral allyl esters having chirality at the α- position of the ester carbonyl group, such as (S)-proline and other (S)-α- amino acid allyl esters, have been found to serve as good asymmetric allylating reagents in palladium-catalyzed reactions of the chiral enamines and imines derived from them. The use of (S)-proline or (S)-valine allyl esters as the amino parts in the enamines or imines provided the highest optical yields of the corresponding α-allyl carbonyl compounds. A mechanism for asymmetric induction is proposed based on the stereochemical results obtained.

SYNTHESIS OF α-ALLYL-α-AMINO ACIDS BY MEANS OF A PALLADIUM CATALYIZED INTRAMOLECULAR REARRANGEMENT

Allylic esters of imines of amino acids provide α-alkylated-α-amino acids in good yields, on rearrangement by catalytic quantities of Pd(0) complexes.