855315-83-2

Upstream product

• 753487-61-5 3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 
• 753487-71-7 2-benzyloxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionic acid ethyl ester 
• 753488-11-8 2-amino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionic acid ethyl ester 
• 753487-53-5 (S)-4-((R)-3-Benzoyloxy-2-methyl-propyl)-5-oxo-oxazolidine-3-carboxylic acid tert-butyl ester 
• 753487-77-3 Benzoic acid (2R,4S)-4-((S)-1-allyloxycarbonyl-ethylcarbamoyl)-4-(tert-butoxycarbonyl-methyl-amino)-2-methyl-butyl ester 
• 855315-80-9 Benzoic acid (2R,4S)-4-((S)-1-allyloxycarbonyl-ethylcarbamoyl)-2-methyl-4-methylamino-butyl ester 
• 753487-47-7 Benzoic acid (2R,4S)-4-(tert-butoxycarbonyl-methyl-amino)-4-carboxy-2-methyl-butyl ester 
• 44812-81-9 L-alanine allyl ester 
• 753487-79-5 benzoic acid 4-(1-allyloxycarbonyl-ethylcarbamoyl)-4-{[3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-methyl-amino}-2-methyl-butyl ester 

Downstream Products

• 753487-86-4 benzoic acid 4-({3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,5-dimethyl-hex-4-enoylamino]-propionyl}-methyl-amino)-4-(1-carboxy-ethylcarbamoyl)-2-methyl-butyl ester 
• 753487-73-9 C₆₅H₈₃N₅O₁₀Si 

Relevant academic research and scientific papers

Macrocyclization studies and total synthesis of cyclomarin C, an anti-inflammatory marine cyclopeptide

The studies on macrocyclization at possible sites toward the total synthesis of cyclomarin C are described. The results showed that both Trp and Phe derivatives involved in the target could not be the terminals of the final linear peptide precursors. Addi

Total synthesis of cyclomarin C

The total synthesis of cyclomarin C was accomplished through a convergent strategy from a tetrapeptide fragment and a tripeptide one. The developed methods to prepare the needed noncoded amino acids, the proper protection of peptide fragments, and identification of the optimum macrocylization site can be applied to further synthetic studies on other members of cyclomarins.