448196-04-1

Basic information

• Product Name: 4-tert-butyl-N-(3-methylphenyl)benzenesulfonamide
• Synonyms: 4-tert-butyl-N-(3-methylphenyl)benzenesulfonamide
• CAS NO: 448196-04-1
• Molecular Formula: C17H21NO2S
• Molecular Weight: 303.41914
• Mol File: 448196-04-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-tert-butyl-N-(3-methylphenyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-butyl-N-(3-methylphenyl)benzenesulfonamide(448196-04-1)
• EPA Substance Registry System: 4-tert-butyl-N-(3-methylphenyl)benzenesulfonamide(448196-04-1)

Safety Data

• Hazardous Substances Data: 448196-04-1(Hazardous Substances Data)

Upstream product

• 15084-51-2 4-tert-butylbenzenesulfonyl chloride 
• 108-44-1 1-amino-3-methylbenzene 

Relevant articles and documents

Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation

Structure-activity relationship studies of substituted arylsulfoanilides as antiproliferatives, which are mediated by the partial depletion of intracellular Ca2+ stores, resulted in the identification of compounds with micromolar activity against lung cancer cells in a growth inhibition assay. Incorporating the substitution pattern of the best arylsulfoanilides onto the 3-phenyloxindole scaffold resulted in a potent arylsulfoanilide-oxindole hybrid, 27. Compound 27 inhibits cancer cell growth by partial depletion of intracellular Ca2+ stores and phosphorylation of eIF2α.