4487-15-4

Usage

Uses

Used in Fragrance Industry:
1-(2-methoxynaphthalen-1-yl)-3-phenylprop-2-en-1-one is used as a fragrance ingredient for its sweet, floral, and spicy scent. It is incorporated into perfumes, soaps, and other personal care products to provide a pleasant aroma.
Used in Skincare Industry:
This chemical is used as an antimicrobial and antioxidant agent in the formulation of skincare products. Its properties help to protect the skin from harmful microorganisms and oxidative stress, promoting healthier and more resilient skin.
However, it is crucial to handle 1-(2-methoxynaphthalen-1-yl)-3-phenylprop-2-en-1-one with care, as it can cause skin and eye irritation and is harmful if ingested. Proper safety measures should be taken during its use in various applications.

Upstream product

• 5672-94-6 1-acetyl-2-methoxynaphthalene 
• 100-52-7 benzaldehyde 
• 93-04-9 2-Methoxynaphthalene 
• 102-92-1 Cinnamoyl chloride 

Downstream Products

• 2860-03-9 3-phenyl-2,3-dihydro-1H-benzo[f]chromen-1-one 
• 75628-63-6 3-(2-methoxy-naphthalen-1-yl)-5-phenyl-4,5-dihydro-isoxazole 
• 75628-35-2 2-[3-(2-Methoxy-naphthalen-1-yl)-3-oxo-1-phenyl-propyl]-cyclohexanone 
• 75628-41-0 2-Acetyl-5-(2-methoxy-naphthalen-1-yl)-5-oxo-3-phenyl-pentanoic acid ethyl ester 
• 75628-39-6 5-(2-Methoxy-naphthalen-1-yl)-1,2,3-triphenyl-pentane-1,5-dione 
• 75628-40-9 1-(3,4-Dimethyl-phenyl)-5-(2-methoxy-naphthalen-1-yl)-2,3-diphenyl-pentane-1,5-dione 
• 75628-42-1 5-(2-Methoxy-naphthalen-1-yl)-5-oxo-2,3-diphenyl-pentanoic acid ethyl ester 
• 75628-44-3 2-Benzoyl-5-(2-methoxy-naphthalen-1-yl)-1,3-diphenyl-pentane-1,5-dione 
• 75628-36-3 2-[3-(2-Methoxy-naphthalen-1-yl)-3-oxo-1-phenyl-propyl]-cyclopentanone 
• 75628-45-4 1-(2-Methoxy-naphthalen-1-yl)-4-methyl-3-phenyl-hexane-1,5-dione 
• 75628-43-2 4-Acetyl-1-(2-methoxy-naphthalen-1-yl)-3-phenyl-hexane-1,5-dione 
• 75628-46-5 2-(4-Chloro-phenyl)-5-(2-methoxy-naphthalen-1-yl)-5-oxo-3-phenyl-pentanenitrile 
• 175795-36-5 4-(2-Methoxy-naphthalen-1-yl)-6-phenyl-5,6-dihydro-1H-pyrimidine-2-thione 
• 175795-44-5 [6-(2-Methoxy-naphthalen-1-yl)-4-phenyl-4,5-dihydro-pyrimidin-2-ylsulfanyl]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site

A series of naphthalene-chalcone derivatives (3a–3t) were prepared and evaluated as tubulin polymerisation inhibitor for the treatment of breast cancer. All compounds were evaluated for their antiproliferative activity against MCF-7 cell line. The most of compounds displayed potent antiproliferative activity. Among them, compound 3a displayed the most potent antiproliferative activity with an IC50 value of 1.42 ± 0.15 μM, as compared to cisplatin (IC50 = 15.24 ± 1.27 μM). Additionally, the promising compound 3a demonstrated relatively lower cytotoxicity on normal cell line (HEK293) compared to tumour cell line. Furthermore, compound 3a was found to induce significant cell cycle arrest at the G2/M phase and cell apoptosis. Compound 3a displayed potent tubulin polymerisation inhibitory activity with an IC50 value of 8.4 μM, which was slightly more active than the reference compound colchicine (IC50 = 10.6 μM). Molecular docking analysis suggested that 3a interact and bind at the colchicine binding site of the tubulin.