448897-29-8

Upstream product

• 13218-13-8 nitroacetonitrile 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 247079-74-9 2-amino-4-(3-methoxy-phenyl)-3-nitro-4H-pyrano[3,2-c]chromen-5-one 
• 247079-71-6 2-amino-4-(3-methoxy-phenyl)-7-methyl-3-nitro-4H-pyrano[4,3-b]pyran-5-one 

Relevant academic research and scientific papers

Effect of microwave irradiation on reaction of arylaldehyde derivatives with some active methylene compounds in aqueous media

The effect of microwave irradiation on the condensation reactions of arylaldehydes 1 and active methylene compounds 2 in aqueous media was studied and compared with "classical" conditions. The results show that the condensation was carried out only under microwave irradiation in the presence of ammonium chloride as a catalyst, followed by dehydration, to afford (E)-olefins 3. The protocol was used to synthesize coumarins by a condensation reaction of salicylaldehyde or its derivatives with various derivatives of ethylacetate 5 (e.g., R3CH2CO2Et; R3: CO 2Et, CO2Me, COMe, CN) in high yields. These investigations will contribute to the development of environmentally friendly and inexpensive processes in organic synthesis.