448904-47-0

Basic information

• Product Name: DESVENLAFAXINE SUCCINATE
• Synonyms: Desvenlafaxine (O-DesMethyl Venlafaxine) Succinate;O-Desmethylvenlafaxine succinate;O-DESMETHYL VENLAFAXINE SUCCINATE IMPURITIES;O-DESMETHYL VENLAFAXIN SUCCINATE
• CAS NO: 448904-47-0
• Molecular Formula: C₄H₆O₄*C₁₆H₂₅NO₂
• Molecular Weight: 381.47
• Mol File: 448904-47-0.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DESVENLAFAXINE SUCCINATE(CAS DataBase Reference)
• NIST Chemistry Reference: DESVENLAFAXINE SUCCINATE(448904-47-0)
• EPA Substance Registry System: DESVENLAFAXINE SUCCINATE(448904-47-0)

Safety Data

• Hazardous Substances Data: 448904-47-0(Hazardous Substances Data)

Usage

Uses

WY 45233 Succinate has been used in the treatment of major depressive disorder (MDD).

Upstream product

• 93413-69-5 1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexanol 
• 99300-78-4 venlafaxine hydrochloride 
• 108-94-1 cyclohexanone 
• 104-47-2 p-methoxybenzylnitrile 
• 110-15-6 succinic acid 
• 93413-62-8 O-desmethylvenlafaxine 

Downstream Products

• 386750-22-7 [2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl)ethyl]dimethylammonium 3-carboxypropanoate monohydrate 

Relevant articles and documents

POLYMORPHIC FORMS OF O-DESMETHYL-VENLAFAXINE SUCCINATE FIELD OF THE INVENTION

The present invention discloses polymorphic forms of O-desmethyl-venlafaxine succinate and processes for the preparation thereof.

PROCESS FOR THE PREPARATION OF O-DESMETHYL-VENLAFAXINE AND SALTS THEREOF

The present invention relates to a novel process for the preparation of O-desmethyl venlafaxine (ODV) and the pharmaceutically acceptable salts thereof, wherein it comprises (i) provision of spiro-venlafaxine compound as intermediate; (ii) conversion of spiro-venlafaxine intermediate into ODV free base in a one-pot process; and (iii) optionally conversion ODV free base into pharmaceutically acceptable salts. The present invention further relates to novel processes for the preparation of crystalline salts of OD V-succinate and ODV-oxalate.

Method for preparation of o-desmethylvenlafaxine using polythiolates

This invention relates to methods of making O-desmethylvenlafaxine from venlafaxine. In the methods venlafaxine is contacted with a polythiolate. The polythiolate may be prepared from the corresponding polythiol in the presence of base. The present methods provide the O-desmethylvenlafaxine in good yields and high purity and are suitable for use on an industrial scale.