448944-47-6

Basic information

• Product Name: N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide
• Synonyms: N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide;melitane;melitane/acetylhexapeptide-1
• CAS NO: 448944-47-6
• Molecular Formula: C₄₃H₅₉N₁₃O₇
• Molecular Weight: 870.01146
• Mol File: 448944-47-6.mol

Chemical Properties

• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• PKA: 13.36±0.46(Predicted)
• CAS DataBase Reference: N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide(448944-47-6)
• EPA Substance Registry System: N-Acetyl-L-norleucyl-L-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophanamide(448944-47-6)

Safety Data

• Hazardous Substances Data: 448944-47-6(Hazardous Substances Data)

Usage

Description

Acetyl hexapeptide-1 is a synthetic peptide composed of the amino acids alanine, arginine, histidine, leucine, phenylalanine and tryptophan. It helps skin better defend itself from environmental aggressors by virtue of a calming effect. This peptide can also help promote a visibly more even skin tone by playing a role in how melanin moves through skin.Acetyl Hexapeptide-1 is a bit of a special snowflake among peptides as it's not a wrinkle-smoothing, anti-aging active like most of the other ones but it can stimulate pigmentation and melanin production (by interacting with a skin cell receptor called MC1R).As melanin not only gives the skin its nice tanned color but also works as a natural protection factor, Acetyl Hexapeptide-1, aka Melitane does the same. It not only boosts a natural or an artificial tan but gives extra protection against UV-induced DNA and free radical damage and protects the skin against UV-caused redness.

Definition

Acetyl Hexapeptide-1 is the reaction product of Alanine, arginine, histidine, leucine, phenylalanine and tryptophane hexapeptide with acetic acid. It activates the regulation of melanin synthesis, relating the protection of natural light and inflammatory regulator.

Application

Acetyl Hexapeptide-1 works as a bio-α-MSH peptide analog. It stimulates hair pigmentation, darkens hair and reverses the gray hair process. It also can help repair DNA damage caused by UV exposure and reduce the skin erythema.

benefits

Acetyl Hexapeptide-1has affinity to MC1-R, which is a biomimeticpeptide simulating a-MSH, promote melaninproduction by combining with MC1-R,lt alsopromotes transfer melanin from melanocytes tokeratinocytes, coloring the hair.Its recommended dosage is 0.1~5%.