448961-29-3

Upstream product

• 448961-06-6 (4S,5S,9R,10R,1'R,5'R)-methyl 8-bromo-4-t-butyldiphenylsilyloxy-1,7-dioxo-9-{2''-[5'-(3-furyl)-1'-methyl-2'-oxocyclopent-1'-yl]-eth-1''-yl}-decahydronaphthalene-10-carboxylate 
• 448961-33-9 (4R,4aR,8S,8aS)-3-Bromo-8-(tert-butyl-diphenyl-silanyloxy)-4-[2-((1R,2R)-2-furan-3-yl-1-methyl-5-oxo-cyclopentyl)-ethyl]-2,5-dioxo-octahydro-naphthalene-1,4a-dicarboxylic acid 1-tert-butyl ester 4a-methyl ester 
• 448961-04-4 (4Z,2'R,3'R)-4-t-butyl bromo-7-[3'-(3-furyl)-2'-methyl-1'-oxocyclopent-2'-yl]-3-oxohept-4-enoate 
• 415928-19-7 (4S)-4-t-butyldiphenylsilyloxy-2-carbomethoxycyclohex-2-en-1-one 

Downstream Products

• 448961-30-6 (4S,5S,8R,9S,10S,13R,14S,17S)-methyl 4-t-butyldiphenylsilyloxy-1,7-dioxo-17-(3-furyl)-14-hydroxyandrostane-10-carboxylate methyl 

Relevant academic research and scientific papers

Studies Directed toward Asymmetric Synthesis of Cardioactive Steroids via Anionic Polycyclization

(Matrix Presented) The use of anionic polycyclization (AP) in constructing the steroidal backbone of cardenolides was investigated. The reaction of 2-carbomethoxy-2-cyclohexenone I with the enolate of Nazarov reagent II gave, after decarboxylation and ald

A convergent synthesis of the cardenolide skeleton: Intramolecular aldol condensation via reduction of α-bromoketones

Synthesis of the highly biologically valuable cardenolide backbone was achieved via anionic polycyclization. Bromoketone 18, obtained from double-Michael cycloaddition between cyclohexenone 14 and γ,δ-unsaturated β-ketoester 16, was efficiently aldolized under reductive conditions. The highly functionalized tetracyclic compound 52 is an important synthetic intermediate that is potentially amenable to natural cardenolide total synthesis.