448961-36-2

Upstream product

• 5707-04-0 Phenylselenyl chloride 
• 448961-24-8 (4S)-4-t-butyldiphenylsilyloxy-2-carbomethoxycyclohexan-1-one 
• 448961-26-0 (4S,2'S)-methyl 4-t-butyldiphenylsilyloxy-1-(1'-hydroxybut-2'-yl)-aminocyclohex-2-ene-2-carboxylate 
• 448961-23-7 rac-4-t-butyldiphenylsilyloxy-2-carbomethoxycyclohexan-1-one 
• 130745-59-4 4-<(tert-Butyldiphenylsilyl)oxy>cyclohexanone 

Downstream Products

• 415928-19-7 (4S)-4-t-butyldiphenylsilyloxy-2-carbomethoxycyclohex-2-en-1-one 

Relevant academic research and scientific papers

A convergent synthesis of the cardenolide skeleton: Intramolecular aldol condensation via reduction of α-bromoketones

Synthesis of the highly biologically valuable cardenolide backbone was achieved via anionic polycyclization. Bromoketone 18, obtained from double-Michael cycloaddition between cyclohexenone 14 and γ,δ-unsaturated β-ketoester 16, was efficiently aldolized under reductive conditions. The highly functionalized tetracyclic compound 52 is an important synthetic intermediate that is potentially amenable to natural cardenolide total synthesis.