4490-74-8Relevant academic research and scientific papers
Cationic lipids for oligonucleotide delivery
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Page/Page column 25; 26, (2017/07/01)
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is susceptible to hydrolytic instability that may translate into reduced liver residence times and reduced hepatocellular toxicity. The present invention employs acetals and ketals to provide a low pH sensitive chemical handle for degradation.
ANDROGEN RECEPTOR MODULATING COMPOUNDS
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Page/Page column 70, (2011/05/11)
Compounds of formula (I) wherein R1 to R16, A. B and E are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.
NOVEL FUNGICIDES
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Page/Page column 76, (2009/04/25)
Compounds of the general formula (I), wherein the substituents are as defined in claim 1, are useful as fungicides.
