4491-45-6

Basic information

• Product Name: 1-tert-butyl 3-methyl 2-phenylmalonate
• Synonyms: 1-tert-butyl 3-methyl 2-phenylmalonate
• CAS NO: 4491-45-6
• Molecular Weight: 250.295
• Mol File: 4491-45-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-tert-butyl 3-methyl 2-phenylmalonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butyl 3-methyl 2-phenylmalonate(4491-45-6)
• EPA Substance Registry System: 1-tert-butyl 3-methyl 2-phenylmalonate(4491-45-6)

Safety Data

• Hazardous Substances Data: 4491-45-6(Hazardous Substances Data)

Upstream product

• 197520-92-6 6-Methoxy-2,2-dimethyl-5-phenyl-[1,3]dioxin-4-one 
• 75-65-0 tert-butyl alcohol 
• 40710-05-2 1-(tert-butyl) 3-methyl 2-diazomalonate 
• 934-56-5 trimethyl(phenyl)stannane 
• 15231-78-4 2.2-dimethyl-5-phenyl-1,3-dioxane-4,6-dione 
• 2996-92-1 phenyl trimethylsiloxane 

Downstream Products

• 1007121-13-2 (S)-1-tert-butyl 3-methyl 2-fluoro-2-phenylmalonate 
• 1133466-69-9 1-tert-butyl 3-methyl (S)-2-hydroxy-2-phenylmalonate 

Relevant articles and documents

Rh(I)-catalyzed cross-coupling of α-diazoesters with arylsiloxanes

An Rh(I)-catalyzed cross-coupling of diazoesters with arylsiloxanes has been successfully achieved. This transformation is a new method for the construction of the C(sp3)-C(sp2) bond, thus providing an alternative synthesis of α-aryl esters. Rh(I)-carbene migratory insertion has been proposed to be involved in this coupling reaction. The reaction represents the first example of utilizing arylsiloxane as the coupling partner in the carbene-involved cross-coupling reactions.

An efficient method for generation of α-oxoketenes: Cycloreversion of enolized Meldrum's acid derivatives

A series of 6-methoxy- or siloxy-4H-1,3-dioxin-4-ones was synthesized from Meldrum's acids. These dioxinones underwent 4+2 cycloreversion to methoxy- or siloxycartbonylketenes and ketones quantitatively at 20-50°C. The ketenes were characterized by IR spectroscopy as well as by trapping with t-butanol. The ready cycloreversion of these enolized Meldrum's acid derivatives strongly indicates that the anomalously high susceptibility of Meldrum's acids to nucleophilic reagents is due to the participation of carboxyketenes generated through the cycloreversion of tautomeric 6-hydroxydioxinones.