44914-03-6

Basic information

• Product Name: 2-methylbutyl acrylate
• Synonyms: ACRYLIC ACID 2-METHYL-BUTYL ESTER;Propenoic acid 2-methylbutyl ester
• CAS NO: 44914-03-6
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.19556
• EINECS: 256-170-3
• Mol File: 44914-03-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: -65.52°C (estimate)
• Boiling Point: 169.78°C (estimate)
• Flash Point: 45.4°C
• Appearance: /
• Density: 0.8936
• Vapor Pressure: 2.08mmHg at 25°C
• Refractive Index: 1.4240
• CAS DataBase Reference: 2-methylbutyl acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylbutyl acrylate(44914-03-6)
• EPA Substance Registry System: 2-methylbutyl acrylate(44914-03-6)

Safety Data

• Hazardous Substances Data: 44914-03-6(Hazardous Substances Data)

Usage

General Description

2-Methylbutyl acrylate, also known as 2-Methyl-1-butyl acrylate, is a chemical compound that belongs to the family of acrylate esters. It is a clear, colorless liquid with a fruity odor and is commonly used as a building block in the production of polymers and resins. This chemical is often utilized in the manufacturing of adhesives, coatings, and sealants due to its high reactivity and ability to form strong bonds. Additionally, 2-Methylbutyl acrylate is also utilized as a raw material in the production of various plastic and rubber products. However, it is important to handle this compound with caution as it can be harmful if inhaled or absorbed through the skin, and may cause irritation to the respiratory system and skin.

InChI:InChI=1/C8H14O2/c1-4-7(3)6-10-8(9)5-2/h5,7H,2,4,6H2,1,3H3

Upstream product

• 137-32-6 (+/-)-2-methyl-1-butanol 
• 814-68-6 acryloyl chloride 

Downstream Products

• 132876-38-1 1-[2-(2-Methyl-butoxycarbonyl)-ethyl]-4-(phenyl-propionyl-amino)-piperidine-4-carboxylic acid methyl ester 

Relevant articles and documents

Design, Synthesis, and Pharmacological Evaluation of Ultrashort- to Long-Acting Opioid Analgetics

In an effort to discover a potent ultrashort-acting μ opioid analgetic that is capable of metabolizing to an inactive species independent of hepatic function, several classes of 4-anilidopiperidine analgetics were synthesized and evaluated.One series of compounds displayed potent μ opioid agonist activity with a high degree of analgesic efficacy and an ultrashort to long duration of action.These analgetics, 4-(methoxycarbonyl)-4--1-piperidinepropanoic acid alkyl esters, were evaluated in vitro in the guinea pig ileum for μ opioid activity, in vivo in the rat tail withdrawal assay for analgesic efficacy and duration of action, and in vitro in human whole blood for their ability to be metabolized in blood.Compounds in this series were all shown to be potent μ agonists in vitro, but depending upon the alkyl ester substitution the potency and duration of action in vivo varied substantially.The discrepancies between the in vitro and in vivo activities and variations in duration of action are probably due to different rates of ester hydrolysis by blood esterase(s).The SAR with respect to analgesic activity and duration of action as a function of the various esters synthesized id discussed.It was also demonstrated that the duration of action for the ultrashort-acting analgetic, 8, does not change upon prolonged infusion or administration of multiple bolus injections.