449173-38-0

Basic information

• Product Name: 3-amino-4-(2-phenylethynyl)pyridine
• Synonyms: 3-amino-4-(2-phenylethynyl)pyridine
• CAS NO: 449173-38-0
• Molecular Weight: 194.236
• Mol File: 449173-38-0.mol

Chemical Properties

• CAS DataBase Reference: 3-amino-4-(2-phenylethynyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-4-(2-phenylethynyl)pyridine(449173-38-0)
• EPA Substance Registry System: 3-amino-4-(2-phenylethynyl)pyridine(449173-38-0)

Safety Data

• Hazardous Substances Data: 449173-38-0(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 105752-11-2 4-iodopyridin-3-amine 

Downstream Products

• 945608-00-4 2-phenylpyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester 
• 2922-07-8 2-phenyl-1H-pyrrolo[2,3-c]pyridine 

Relevant articles and documents

Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes

High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.

Synthesis of novel heteroaromatics structurally related to ellipticine alkaloids via thermolysis of pyridannulated enyne-carbodiimides

New synthetic pathways to the 5H-pyrido[3',4':4,5]pyrrolo[2,3-b]quinolines 6, the 6H-pyrido[3',4':4,5]pyrrolo[2,3-b] [1,6]naphthyridines 7, and the 11H-pyrido[43,3': 4,5]pyrrolo[2,3-b]quinolines 8 via thermolysis of the pyridannulated enyne-carbodiimides 14, 19, and 23 were established. These novel heteroaromatic systems are structurally related to ellipticine alkaloids and could serve as DNA- intercalating agents.