4492-50-6

Usage

Uses

Used in Pharmaceutical Industry:
Cyclopentanecarboxamide, N-methylis employed as an intermediate in the synthesis of pharmaceutical compounds, contributing to the development of new drugs and medications.
Used in Chemical Industry:
In the chemical industry, Cyclopentanecarboxamide, N-methylserves as an intermediate for the production of various organic compounds, facilitating the creation of a range of chemical products.
Used in Research and Development:
Cyclopentanecarboxamide, N-methylis utilized in research and development, particularly in medicinal chemistry, to explore its properties and potential applications in creating new pharmaceutical agents.

InChI:InChI=1/C7H13NO/c1-8-7(9)6-4-2-3-5-6/h6H,2-5H2,1H3,(H,8,9)

Upstream product

• 58265-19-3 3-methyl-3,4,5,6,7,7a-hexahydro-benzo[1,2,3]triazol-3a-ol 
• 874-23-7 2-acetylcyclohexanone 
• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 
• 51871-58-0 2,5-dioxopyrrolidin-1-yl cyclopentanecarboxylate 
• 4524-93-0 Cyclopentanecarboxylic acid chloride 
• 3400-45-1 cyclopentanecarboxylic acid 
• 123-39-7 N-Methylformamide 
• 142-29-0 cyclopentene 

Downstream Products

• 4492-51-7 1-cyclopentanemethyl-N-methylamine 

Relevant academic research and scientific papers

Effects of backbone rigidification on intramolecular hydrogen bonding in a family of diamides

In an effort to gain insight on the balance of noncovalent forces that controls the adoption of folded conformations in small molecules, we have examined intramolecular hydrogen bond formation in a series of diamides containing a variety of conformational

Direct Copper-Catalyzed Three-Component Synthesis of Sulfonamides

First introduced into medicines in the 1930s, the sulfonamide functional group continues to be present in a wide range of contemporary pharmaceuticals and agrochemicals. Despite their popularity in the design of modern bioactive molecules, the underpinning methods for sulfonamide synthesis are essentially unchanged since their introduction, and rely on the use of starting materials with preinstalled sulfur-functionality. Herein we report a direct single-step synthesis of sulfonamides that combines two of the largest monomer sets available in discovery chemistry, (hetero)aryl boronic acids and amines, along with sulfur dioxide, using a Cu(II) catalyst, to deliver a broad range of sulfonamides. Sulfur dioxide is provided by the surrogate reagent DABSO. The reaction tolerates broad variation in both coupling partners, including aryl, heteroaryl and alkenyl boronic acids, as well as cyclic and acyclic alkyl secondary amines, and primary anilines. We validate the method by showing that a variety of drugs, and drug-fragments, can be incorporated into the process.

Selective α-Oxyamination and Hydroxylation of Aliphatic Amides

Compared to the α-functionalization of aldehydes, ketones, even esters, the direct α-modification of amides is still a challenge because of the low acidity of α-CH groups. The α-functionalization of N?H (primary and secondary) amides, containing both an unactived α-C?H bond and a competitively active N?H bond, remains elusive. Shown herein is the general and efficient oxidative α-oxyamination and hydroxylation of aliphatic amides including secondary N?H amides. This transition-metal-free chemistry with high chemoselectivity provides an efficient approach to α-hydroxy amides. This oxidative protocol significantly enables the selective functionalization of inert α-C?H bonds with the complete preservation of active N?H bond.

Dodecacarbonyltriruthenium catalyzed one-to-one addition of N-substituted formamides to olefins

Dodecacarbonyltriruthenium (Ru3(CO)12) showed high catalyitic activity for the first one-to-one addition of N-substituted formamides to both terminal and internal olefins at 180-200 deg C under a carbon monoxide pressure of 20 kg cm-2.The addit